Clincosm LogoSign in Get a demo

Immunological Interaction Between the Host and Candida Albicans Biofilm

Sponsor
Universitaire Ziekenhuizen Leuven (Other)
Overall Status
Completed
CT.gov ID
NCT01919931
Collaborator
(none)
237
Enrollment
1
Location
34
Duration (Months)
7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Candida albicans is one of the most common nosocomial infection and the onset relies on the host immune status. The purpose of this study is to determine the immunological profile of patients infected with Candida albicans, that could ideally lead to a strategy to identify patients who could benefit from prophylaxis.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    237 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Immunological and Molecular Interaction Between the Host and Candida Albicans Biofilm
    Study Start Date :
    Mar 1, 2013
    Actual Primary Completion Date :
    Aug 1, 2015
    Actual Study Completion Date :
    Jan 1, 2016

    Arms and Interventions

    Arm Intervention/Treatment
    Candida Infection

    Patients infected with Candida albicans
    No infection

    Patients with no Candida albicans infection

    Outcome Measures

    Primary Outcome Measures

    1. Immunological phenotyping of patients [2 months]

    Secondary Outcome Measures

    1. Mannose Binding Lectin levels [1 month]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Patients infected with Candida albicans

    • Patients not infected with Candida albicans

    Exclusion Criteria:

    • Underage patients

    • Non consenting patients

    • Unconscious patients

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Universitair Ziekenhuis Leuven Leuven Flemish Brabant Belgium 3000

    Sponsors and Collaborators

    • Universitaire Ziekenhuizen Leuven

    Investigators

    • Study Director: Adrian Liston, Group Leader, Flemish Institute of Biotechnology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Universitaire Ziekenhuizen Leuven
    ClinicalTrials.gov Identifier:
    NCT01919931
    Other Study ID Numbers:
    • S55012
    First Posted:
    Aug 9, 2013
    Last Update Posted:
    Dec 7, 2016
    Last Verified:
    Dec 1, 2016
    Keywords provided by Universitaire Ziekenhuizen Leuven
    Candida albicans
    Candidiasis
    Biofilm
    Flow cytometry
    Mannose Binding Lectin
    Additional relevant MeSH terms:
    Candidiasis

    Study Results

    No Results Posted as of Dec 7, 2016