Impact of Bariatric Surgery on Cardiorespiratory Function
Study Details
Study Description
Brief Summary
Obesity is a growing problem worldwide and its prevention has become one of the leading priorities for the World Health Organisation. Obesity results from chronic imbalance between energy intake and energy expenditure. Although early prevention of obesity is preferable, surgical treatment is often required for severely obese people.
Bariatric surgery has been shown to be the most effective therapy for severe obesity. Weight loss following bariatric surgery results in significant improvements in coexisting comorbidities, such as diabetes and hypertension but there is controversy whether bariatric surgery also improves aerobic capacity.
The purpose of this study is to investigate the effects of bariatric surgery on cardiopulmonary function and on daily physical activity. It is hypothesized that bariatric surgery will improve aerobic capacity and result in beneficial lifestyle changes from sedentary to more active.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- Cardiorespiratory function assessed by peak oxygen consumption (VO2peak) [One to two weeks before surgery and six months after surgery]
Secondary Outcome Measures
- Lung function [One to two weeks before surgery and six months after surgery]
Lung function will be assessed by spirometry and body plethysmography
- Heart function [One to two weeks before surgery and six months after surgery]
Echocardiography will be performed to assess heart function.
- Inspiratory muscle strength [One to two weeks before surgery and six months after surgery]
Maximal inspiratory pressure and sniff nasal pressure will be recorded.
- Peripheral muscle strength [One to two weeks before surgery and six months after surgery]
Maximum isometric strength of hand/ forearm, quadriceps and hip flexors muscles will be evaluated
- Free living sedentary and physical activity times [One to two weeks before surgery and six months after surgery]
Daily physical activity habits will be assessed by an accelerometer and International Physical Activity Questionnaire: Long (IPAQ-Long). Participants will be required to wear the accelerometer for four consecutive days during the two study points.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Ages 18 years to 50 years
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Patients enrolled in the bariatric surgery program of St George's Hospital with BMI > 40 kg/m2, or 35-40 kg/m2 in the presence of other obesity-related comorbidities such as hypertension or type- 2 diabetes
Exclusion Criteria:
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Locomotor difficulties which would prevent participants from completing the cardiopulmonary exercise testing
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Weight > 190 kg (due to weight restrictions of equipment used to transfer patients in the event of medical emergencies)
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Cognitive impairment
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Patients unable to follow instructions in English
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | St George's Healthcare NHS Trust | London | United Kingdom | SW17 0RE |
Sponsors and Collaborators
- St George's, University of London
- Universidade Federal do Triangulo Mineiro
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Investigators
- Principal Investigator: Marcia S Volpe, Universidade Federal Triangulo Mineiro
- Study Chair: Dimitra Nikoletou, Kingston University and St George's University of London
- Study Director: Marcus Reddy, St George's Healthcare NHS Trust
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 13.0217