Impact of Core Performance on Functional Parameters in Multiple Sclerosis

Sponsor

Istanbul University-Cerrahpasa (Other)

Overall Status

Completed

CT.gov ID

NCT04750733

Collaborator

(none)

Enrollment

Location

16.4

Actual Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Optimal trunk control relies on somatosensory, motor and musculoskeletal integrity, which is often damaged in multiple sclerosis (MS). Researches on postural control in people with MS (PwMS) have revealed that reduced somatosensory conduction may adversely affect some functions. PwMS have increased postural sway in upright posture than healthy people. They move closer and slower when reaching out or taking a step. Trunk controls are weak and postural responses are delayed. The activation of core muscles is very important for an effective trunk control. Because the core region is considered a kinetic link that facilitates the transfer of torque and angular momentum between the upper and lower extremities during body movements. The decrease in core stability affects both trunk control and the quality of limb movements due to the kinetic chain in the body. There are a limited number of studies in the literature showing that core stability is reduced in PwMS. Our knowledge about the effects of this reduction on function in PwMS is very limited.

Condition or Disease	Intervention/Treatment	Phase
Multiple Sclerosis	Other: Assessment

Detailed Description

The aim of this study is to evaluate core strength and endurance and determine its effect on postural control, knee muscle strength, physical capacity and fatigue parameters in individuals with MS. Also relationship between these parameters will investigate.

Study Design

Study Type:

Observational

Actual Enrollment :

50 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Impact of Core Performance on Functional Parameters in Multiple Sclerosis

Actual Study Start Date :

Feb 20, 2021

Actual Primary Completion Date :

Jul 1, 2022

Actual Study Completion Date :

Jul 5, 2022

Arms and Interventions

Arm	Intervention/Treatment
Multiple Sclerosis Ambulatory MS patients	Other: Assessment Assessment of core strength and endurance, muscle strength, postural sway in different condition, physical capacity and fatigue

Arm

Intervention/Treatment

Multiple Sclerosis

Ambulatory MS patients

Other: Assessment

Assessment of core strength and endurance, muscle strength, postural sway in different condition, physical capacity and fatigue

Outcome Measures

Primary Outcome Measures

Core strength [Baseline]
Core strength will be evaluated within the scope of core assessment. Curl-Up and Modified Push-Up test will be used for the evaluation of core strength.
Core endurance [Baseline]
Core endurance will be evaluated within the scope of core assessment. Trunk flexor, extensor, lateral endurance and plank will be used in the evaluation of core endurance and recorded as seconds.
Postural sway [Baseline]
Postural sways will be evaluated with biodex balance system in different condition such as open eyes on firm and foam surface, closed eyes on firm and foam surface, double stance on firm and foam surface, tandem stance on firm and foam surface.
İsokinetic strength [Baseline]
Concentric isokinetic muscle strength of the knee flexor and extensor muscles will be evaluated with Biodex isokinetic dynamometer at angular velocities of 30,60 and 90°/s.

Secondary Outcome Measures

Physical capacity [Baseline]
Two-minute walk test (2-MWT) will be used to evaluate the mobility of the people with MS. 2-MWT is a measure of self-paced walking ability and functional capacity.
Mobility [Baseline]
Timed Up and Go (TUG) will be used. TUG is a test used to determine fall risk and measure the progress of balance, sit to stand and walking.
Fatigue [Baseline]
Fatigue Severity Scale (FSS) will be used to evaluate fatigue levels. This scale evaluates the severity of fatigue with 9 questions. Each question scores between 1 (I do not agree) and 7 (fully agree). The FSS score is the average value of nine sections. A high score indicates increased fatigue severity.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Being diagnosed with MS according to McDonald's criteria
Disability level less than 6 according to EDSS (Expanded Disability Status Scale) score
No attacks during the last 3 months
Being an ambulatory
Volunteering to participate in the study

Exclusion Criteria:

Having orthopedic, neurological, psychological, etc. diseases that accompany MS and may affect treatment outcomes
Doing regular sports
Being involved in another physiotherapy and rehabilitation program related to MS