Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents

Sponsor

University of Electronic Science and Technology of China (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05981612

Collaborator

(none)

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.

Condition or Disease	Intervention/Treatment	Phase
Nonsuicidal Self Injury Prediction Errors

Study Design

Study Type:

Observational

Anticipated Enrollment :

80 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury

Anticipated Study Start Date :

Aug 1, 2023

Anticipated Primary Completion Date :

Jul 1, 2026

Anticipated Study Completion Date :

Jul 1, 2027

Arms and Interventions

Arm	Intervention/Treatment
NSSI
HC

Outcome Measures

Primary Outcome Measures

Reward prediction errors (PEs) [About 20 minutes]
Reward PEs will be calculated by the differences between the experienced (when be offered) reward and predicted (before the offer) reward.
Valence prediction errors (PEs) [About 20 minutes]
Valence PEs will be calculated by the differences between the experienced emotional valence and predicted emotional valence.
Arousal prediction errors (PEs) [About 20 minutes]
Arousal PEs will be calculated by the differences between the experienced emotional arousal and predicted emotional arousal.
The prediction of PEs of punishment decisions [About 20 minutes]
All PEs and groups (NSSI, HC) will be used in a regression model to examined whether there is any alteration in the NSSI group when PEs are predicted to punishment (reject) decisions.

Eligibility Criteria

Criteria

Ages Eligible for Study:

15 Years to 18 Years

Sexes Eligible for Study:

All

Inclusion Criteria:

15-18 years
right-handed
normal or corrected normal visual acuity
meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)

Exclusion Criteria:

diagnosis of borderline personality disorder, major depressive disorder, other
psychiatric disorders, etc.
high suicidal risk
recent use of medications that can affect neural activity
have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

University of Electronic Science and Technology of China

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Benjamin Becker, Professor, University of Electronic Science and Technology of China

ClinicalTrials.gov Identifier:

NCT05981612

Other Study ID Numbers:

BAM_lab_NSSI_04

First Posted:

Aug 8, 2023

Last Update Posted:

Aug 8, 2023

Last Verified:

Aug 1, 2023

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Self-Injurious Behavior

Study Results

No Results Posted as of Aug 8, 2023