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Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

Sponsor
Xijing Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT01201655
Collaborator
Air Force Military Medical University, China (Other), Health Science Center of Xi'an Jiaotong University (Other)
5,000
Enrollment
1
Location
35
Duration (Months)
142.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to investigate the impact of splenectomy coupled with portal-azygous disconnection on hepatocarcinogenesis in patients with post-hepatitic cirrhosis after hepatitis B or C virus infection by retrospective case-control study,We hope to find a new idear and method to prevent or cure HCC.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    A case-control study was carried out. The factors studied include age, gender, ascites, hepatic encephalopathy, ALT, AST, TBIL, ALP, GGT, Child-Pugh classification of liver function, and history of splenectomy with portal-azygous disconnection during the treatment of portal hypertension. According to the Child-Pugh classification, these cases were graded as A, B, and C. And according to the ranges of the normal reference values of the data, they were categorized into two groups including a normal group and an abnormal group.The data mainly comes from FMMU and Xi'an jiaotong university from the year of 2002 to 2012.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    5000 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Multicentric Retrospective Case Control Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis
    Study Start Date :
    Jan 1, 2010
    Anticipated Primary Completion Date :
    Dec 1, 2012
    Anticipated Study Completion Date :
    Dec 1, 2012

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years to 90 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • after surgery
      Exclusion Criteria:
      • without surgery

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Chen yong Xi'an Shaanxi China 710032

      Sponsors and Collaborators

      • Xijing Hospital
      • Air Force Military Medical University, China
      • Health Science Center of Xi'an Jiaotong University

      Investigators

      • Study Director: Chen yong, professor, Xia jielai

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT01201655
      Other Study ID Numbers:
      • chenyong
      First Posted:
      Sep 14, 2010
      Last Update Posted:
      Sep 14, 2010
      Last Verified:
      Jan 1, 2010
      Keywords provided by , ,
      Posthepatitic cirrhosis;
      Hepatocarcinogenesis;
      Splenectomy;
      Additional relevant MeSH terms:
      Carcinoma, Hepatocellular
      Liver Cirrhosis
      Hypersplenism
      Fibrosis
      Splenomegaly

      Study Results

      No Results Posted as of Sep 14, 2010