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THINK: Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia

Sponsor
Hopital Foch (Other)
Overall Status
Completed
CT.gov ID
NCT02948465
Collaborator
(none)
125
Enrollment
1
Location
4.6
Actual Duration (Months)
27
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Cerebral infarcts represent a major cause of morbidity/mortality in spite of therapeutics for a premature recanalisation (intravenous recombinant tissue plasminogen activator (rt-PA) and thrombectomy). Thrombolysis failure by the administration of rt-PA is frequent, in particular in proximal occlusion. Experimental studies suggest that neutrophils could play an important role in the thrombus development via the organization of a network (NET) within the thrombus. Targeting this network of NET could, in addition to the fibrinolysis, increase the rate of recanalisation and thus improve the neurological prognostic after a cerebral infarct.

The aim of the research is to Study of the biochemical and histological composition of the stemming thrombi of cerebral thrombectomies with in vitro analysis of the sensibility in the thrombolysis induced by rt-PA +/- Desoxyribonuclease I (DNase I).

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    125 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia
    Actual Study Start Date :
    Jul 22, 2016
    Actual Primary Completion Date :
    Dec 10, 2016
    Actual Study Completion Date :
    Dec 10, 2016

    Outcome Measures

    Primary Outcome Measures

    1. Correlation coefficient between biochemical and histological composition of the thrombus and the sensibility in the in vitro fibrinolysis and the origin of the thrombus. [1 day]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patient over 18

    • Having a cerebral infarct consecutive to a wide calibre arterial occlusion

    • taken care for mechanical thrombectomy

    Exclusion Criteria:

    • Patient benefiting from a legal protective measure

    • Pregnant or breast-feeding woman

    • Opposition of the patient to participate in the study

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Hopital Foch Suresnes France 92150

    Sponsors and Collaborators

    • Hopital Foch

    Investigators

    • Principal Investigator: Arturo CONSOLI, MD, Hopital Foch
    • Study Chair: Bertrand LAPERGUE, MD, Hopital Foch

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Hopital Foch
    ClinicalTrials.gov Identifier:
    NCT02948465
    Other Study ID Numbers:
    • 2016/37
    First Posted:
    Oct 28, 2016
    Last Update Posted:
    Aug 14, 2019
    Last Verified:
    Aug 1, 2019
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Keywords provided by Hopital Foch
    Neutrophil Extracellular Traps
    Additional relevant MeSH terms:
    Brain Ischemia
    Cerebral Infarction
    Ischemia

    Study Results

    No Results Posted as of Aug 14, 2019