Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild (Other)

Overall Status

Recruiting

CT.gov ID

NCT03408379

Collaborator

(none)

230

Enrollment

Location

179.4

Anticipated Duration (Months)

1.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Condition or Disease	Intervention/Treatment	Phase
Intracranial Aneurysms Ruptured Aneurysm	Other: Collection of blood sample in aneurysm

Study Design

Study Type:

Observational

Anticipated Enrollment :

230 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

Actual Study Start Date :

Dec 20, 2017

Anticipated Primary Completion Date :

Dec 1, 2022

Anticipated Study Completion Date :

Dec 1, 2032

Outcome Measures

Primary Outcome Measures

Proportion of patients with platelet activation [in the 7 days before embolisation]
comparison of this proportion between patients with ruptured versus non ruptured intracranial aneurysm

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patient aged 18 and over
Patient presenting a single or multiple aneurysm
Patient presenting an intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery) : elective intervention for an unruptured aneurysm or emergency surgery for a broken aneurysm