The Impact of Past Coronavirus Disease 19 (COVID-19) Infection on the Live Birth Rates of Frozen Embryo Transfer Cycles
Study Details
Study Description
Brief Summary
This is a prospective observational study. In this study, we aim to investigate the effect of a recent past Covid-19 infection on the live birth rate in the frozen embryo transfer cycles
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| COVID-19 infection group Infertile women attending for frozen embryo transfer with a recent past COVID-19 infection |
Other: frozen embryo transfer
transfer one or two embryos in frozen embryo transfer cycles
|
| Control group Infertile women attending for frozen embryo transfer without a recent past COVID-19 infection |
Other: frozen embryo transfer
transfer one or two embryos in frozen embryo transfer cycles
|
Outcome Measures
Primary Outcome Measures
- live birth rate [a live birth after 22 weeks gestation]
live birth rate of the frozen embryo transfer cycle (>22 weeks of gestation)
Secondary Outcome Measures
- serum hCG level [a blood pregnancy test is performed 14 days after the embryo transfer]
serum hCG level
- clinical pregnancy [presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy]
presence of intrauterine gestational sac on ultrasound
- ongoing pregnancy [viable pregnancy beyond gestation 12 weeks]
viable pregnancy beyond gestation 12 weeks
- biochemical pregnancy [positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation]
positive blood pregnancy test not followed by clinical pregnancy
- implantation rate [number of gestational sacs per embryo transferred during 4 weeks of pregnancy]
number of gestational sacs per embryo transferred
- multiple pregnancy [multiple pregnancy beyond gestation 12 weeks]
more than one intrauterine sacs on scanning
- ectopic pregnancy [ectopic pregnancy during 12 weeks gestation]
pregnancy outside the uterine cavity
- miscarriage [the loss of a pregnancy before 22 weeks gestation]
the loss of a pregnancy before 22 weeks gestation
- birth weight [a live birth after 22 weeks gestation]
birth weight of the baby delivered
- serum COVID-19 antibody level [7 days before embryo transfer]
serum COVID-19 antibody level immunoglobulin G and immunoglobulin M
Eligibility Criteria
Criteria
Inclusion Criteria:
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Women aged 20-42 years at the time of ovarian stimulation for in vitro fertilization
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Women have embryos frozen prior to COVID infection.
Exclusion Criteria:
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Previous COVID infection before oocyte retrieval
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Recipient of oocyte donation
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Undergoing preimplantation genetic testing
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Presence of hydrosalpinx or endometrial polyp which is not surgically treated
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | ShangHai JIAI Genetics&IVF Institute | Shanghai | China |
Sponsors and Collaborators
- ShangHai Ji Ai Genetics & IVF Institute
Investigators
- Study Director: Xiaoxi Sun, PhD, Shanghai JiAi Genetics & IVF Institute
Study Documents (Full-Text)
None provided.More Information
Publications
- Aizer A, Noach-Hirsh M, Dratviman-Storobinsky O, Nahum R, Machtinger R, Yung Y, Haas J, Orvieto R. The effect of coronavirus disease 2019 immunity on frozen-thawed embryo transfer cycles outcome. Fertil Steril. 2022 May;117(5):974-979. doi: 10.1016/j.fertnstert.2022.01.009. Epub 2022 Jan 10.
- Henarejos-Castillo I, Sebastian-Leon P, Devesa-Peiro A, Pellicer A, Diaz-Gimeno P. SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle. Fertil Steril. 2020 Aug;114(2):223-232. doi: 10.1016/j.fertnstert.2020.06.026. Epub 2020 Jun 17.
- Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, Winter H, Meister M, Veith C, Boots AW, Hennig BP, Kreuter M, Conrad C, Eils R. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J. 2020 May 18;39(10):e105114. doi: 10.15252/embj.20105114. Epub 2020 Apr 14.
- Vaz-Silva J, Carneiro MM, Ferreira MC, Pinheiro SV, Silva DA, Silva-Filho AL, Witz CA, Reis AM, Santos RA, Reis FM. The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. Reprod Sci. 2009 Mar;16(3):247-56. doi: 10.1177/1933719108327593. Epub 2009 Jan 22.
- Youngster M, Avraham S, Yaakov O, Landau Rabbi M, Gat I, Yerushalmi G, Baum M, Maman E, Hourvitz A, Kedem A. The impact of past COVID-19 infection on pregnancy rates in frozen embryo transfer cycles. J Assist Reprod Genet. 2022 Jul;39(7):1565-1570. doi: 10.1007/s10815-022-02517-w. Epub 2022 May 7.
- Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020 Apr;14(2):185-192. doi: 10.1007/s11684-020-0754-0. Epub 2020 Mar 12.
- JIAI 2023-01