Effect of Sildenafil on Endothelial Function

• Sponsor: Rambam Health Care Campus (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT00297544
• Collaborator: Pfizer (Industry)
• Enrollment: 60
• Location: 1

Study Details

Study Description

Brief Summary

We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Condition or Disease	Intervention/Treatment	Phase
Impotence	Drug: Viagra	N/A

Detailed Description

We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Study Design

• Study Type: Interventional
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double
• Primary Purpose: Educational/Counseling/Training
• Official Title: Effect of Sildenafil on Endothelial Function
• Study Start Date: Oct 1, 2005

Outcome Measures

Primary Outcome Measures

1. Improvement of endothelial function following Viagra treatment, according to platismographia. []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 40 Years to 70 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• age 40-70

• impotence

• with and without hypertension, Hypercholesteremia or DM

Exclusion Criteria:

• CHF: NYHA > II

• Stable angina: CCS > II

• Nitrate treatment

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Rambam Medical Center, Recanati Autonomic Dysfunction CTR	Haifa		Israel	31096

Sponsors and Collaborators

• Rambam Health Care Campus
• Pfizer

Investigators

• Principal Investigator: Giris Jacob, Prof, MD, DSc, Rambam Health Care Campus

Study Documents (Full-Text)

None provided.

More Information

Publications

• Dayan L, Greunwald I, Vardi Y, Jacob G. A new clinical method for the assessment of penile endothelial function using the flow mediated dilation with plethysmography technique. J Urol. 2005 Apr;173(4):1268-72.

• ClinicalTrials.gov Identifier: NCT00297544
• Other Study ID Numbers: 1777-CTIL
• First Posted: Feb 28, 2006
• Last Update Posted: Feb 28, 2006
• Last Verified: Nov 1, 2005

• Keywords provided by , ,: impotence; endothelial function; autonomic nervous system
• Additional relevant MeSH terms: Erectile Dysfunction; Sildenafil Citrate

Study Results

No Results Posted as of Feb 28, 2006