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Improve Nuclear Medicine Heart Imaging, Compare MRI Results With Single Photon Emission Computed Tomography Imaging

Sponsor
State University of New York - Upstate Medical University (Other)
Overall Status
Completed
CT.gov ID
NCT00639704
Collaborator
(none)
6
Enrollment
1
Location
187
Duration (Months)
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to compare the MRI results with the new SPECT image reconstruction method, this study will allow us to determine whether a new more accurate method of looking at the heart by nuclear study can be used in routine clinical use.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Currently, up to one-third of all nuclear medicine studies are performed for cardiovascular disorders, and mostly are myocardial perfusion imaging (MPI) using SPECT acquisition. MPI aims at detection of acute myocardial ischemia and the scarred myocardium and it is increasingly used to plan myocardial revascularization and to assess the effectiveness of medical and surgical interventions. However, nonuniform gamma-ray attenuation in the thoracic region may severely impair the accuracy of SPECT cardiac imaging and frequently result in image artifacts. Therefore, attenuation corrected must be applied. We have derived an algorithm (called EM-IntraSPECT) that is able to reconstruct tomographic cross-sections of a patient from SPECT studies alone. The reconstructed cross-sections in turn, may be used for attenuation correction of cardiac SPECT images thus improving quality analysis based of these images. In this research we intend to continue evaluation of the new attenuation compensation algorithm and to assess the clinical usefulness of this method. These goals can be reached by comparing the patient's cross sectional anatomical data reconstructed by EM-IntraSPECT and obtained from MRI. It is proposed that 10 patients already undergoing nuclear cardiac imaging for clinical purpose, with 99mTc sestamibi or 99mTc radiolabeled red cells will be selected. These patients would be utilized to reconstruct transmission images and determination of internal anatomical structures in the thoracic region from SPECT projections alone. Further, direct and quantitative comparison of the patient's anatomy obtained by the MRI and the SPECT methods will be performed. The same algorithm would be used for reconstruction of attenuation compensated emission SPECT cardiac images. Finally, the accuracy and the clinical usefulness of this new, attenuation corrected cardiac SPECT image reconstruction would be quantitatively evaluated. All these procedures apply only to the image data and NOT the patient.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    6 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Evaluation of EM-IntraSPECT Reconstruction Algorithm by Comparison of Transmission Images Reconstructed From SPECT Projections Alone With MRI Studies
    Study Start Date :
    Jan 1, 1996
    Actual Primary Completion Date :
    Aug 1, 2011
    Actual Study Completion Date :
    Aug 1, 2011

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • subjects scheduled for cardiac SPECT

      • subjects 18 years old or older

      Exclusion Criteria:

      • Females who are pregnant or think that they are pregnant will be excluded in this study.

      • Subjects who have a pacemaker, internal defibrillator, prostheses, artificial heart valves, cardiac stents, surgical clips, or TENS (transcutaneous electric nerve stimulator)

      • Subjects who are 300 lbs and over

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 SUNY Upstate Medical University Syracuse New York United States 13210

      Sponsors and Collaborators

      • State University of New York - Upstate Medical University

      Investigators

      • Principal Investigator: Andrzej Krol, PhD, State University of New York - Upstate Medical University

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Andrzej Krol, PhD, State University of New York - Upstate Medical University
      ClinicalTrials.gov Identifier:
      NCT00639704
      Other Study ID Numbers:
      • SUNYUMU 3257
      First Posted:
      Mar 20, 2008
      Last Update Posted:
      May 14, 2015
      Last Verified:
      May 1, 2015
      Keywords provided by Andrzej Krol, PhD, State University of New York - Upstate Medical University
      MRI
      SPECT
      Cardiac function

      Study Results

      No Results Posted as of May 14, 2015