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Incidence and Outcomes of Acute Kidney Injury in Trauma Patients Admitted to Critical Care

Sponsor
Ankara University (Other)
Overall Status
Completed
CT.gov ID
NCT05381493
Collaborator
Bengi Şafak (Other), Keziban Sanem Çakar Turhan (Other), Mustafa Onur Karaca (Other), Uğur Aydoğan (Other), Ali Abbas Yılmaz (Other), Mustafa Kemal Bayar (Other)
171
Enrollment
1
Location
16.2
Actual Duration (Months)
10.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Acute kidney injury (AKI) is a common complication that increases lenght of stay and mortality in trauma patients admitted to the intensive care unit (ICU). The aim of this study is to identify the incidence and outcomes of trauma patients, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria, at single center level 3 ICU.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Trauma can cause high mortality and morbidity by affecting different organ systems. Acute kidney injury (AKI) is a common complication in trauma patients admitted to the intensive care unit (ICU). Direct kidney injury, hypotension, hypoperfusion, rhabdomyolysis, abdominal compartment syndrome, sepsis and critical care medications are possible causes of AKI in trauma patients. The incidence of AKI can be up to 10%, and mortality rate up to 60-80% in trauma patients. Since AKI is not only a rare complication but also a risk factor for mortality in critically ill trauma patients, it is essential to establish a strategy to prevent AKI and related complications, to determine the incidence and risk factors of AKI, and to improve patients outcomes. Survivors of AKI may have variable recovery of kidney function and might prone to late morbidity and mortality. In this study incidence of AKI was defined using the KDIGO criteria according to the change of serum creatine levels.

    171 all type of trauma patients admitted to level 3 ICU, from January 2014 to December 2018 included the retrospectve observational study. Demographic data, type of injury, rates of complications, risk factors for AKI, mortality, lenght of stay (LOS) in ICU were evaluated. Acute Physiology and Chronic Health Evaluation (APACHE II and IV) score, Simplified Acute Physiology Score (SAPS II and III), Glasgow Coma Scale (GCS), Injury Severity Score (ISS) and, Trauma Injury Severity Score (TRISS) were calculated on the day of admission. AKI was defined using the KDIGO criteria according to the serum creatinine. The SPSS 11.5 program was used for statistical analysis.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    171 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Incidence and Outcomes of Acute Kidney Injury in Trauma Patients Admitted to Critical Care
    Actual Study Start Date :
    Jan 1, 2021
    Actual Primary Completion Date :
    Feb 28, 2022
    Actual Study Completion Date :
    May 10, 2022

    Outcome Measures

    Primary Outcome Measures

    1. Acute kidney injury in trauma patients [one week]

      Kidney Disease Improving Global Outcomes (KDIGO) criteria

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 97 Years
    Sexes Eligible for Study:
    All
    Inclusion Criteria:
    • all type of trauma patients admitted to level 3 ICU, from January 2014 to December 2018
    Exclusion Criteria:

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Süheyla Karadağ Erkoç Ankara Turkey 06230

    Sponsors and Collaborators

    • Ankara University
    • Bengi Şafak
    • Keziban Sanem Çakar Turhan
    • Mustafa Onur Karaca
    • Uğur Aydoğan
    • Ali Abbas Yılmaz
    • Mustafa Kemal Bayar

    Investigators

    • Principal Investigator: Süheyla Karadağ Erkoç, Ankara University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Süheyla Karadağ Erkoç, Anesthesiology and Reanimation, Ankara University
    ClinicalTrials.gov Identifier:
    NCT05381493
    Other Study ID Numbers:
    • AnkaraUTraumaAKI
    First Posted:
    May 19, 2022
    Last Update Posted:
    May 19, 2022
    Last Verified:
    May 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Süheyla Karadağ Erkoç, Anesthesiology and Reanimation, Ankara University
    Trauma
    Acute Kidney Injury
    Intensive Care Unit
    Additional relevant MeSH terms:
    Acute Kidney Injury
    Wounds and Injuries

    Study Results

    No Results Posted as of May 19, 2022