The Incidence and Risk Factors for Clostridioides Difficle Infection in Solid Organ Transplant Recipients
Study Details
Study Description
Brief Summary
2.1. Study Objectives
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Primary Objective(s)
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Identify the incidence and risk of CDI within one year after kidney, liver, and/or pancreas transplant
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Secondary Objective(s)
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Identify the risk factors for recurrent CDI post-transplant in patients who were diagnosed with a CDI within one year prior to Solid Organ Transplant
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Evaluate the impact of CDI on graft survival following Solid Organ Transplant
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
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Single center, retrospective cohort chart review study design
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Data will be collected on all liver, kidney, pancreas and combined transplant recipients who received their graft(s) from April 1, 2015 to July 31, 2018
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Will analyze outcomes from April 1, 2014 to July 31, 2019
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Patient list will be generated in Epic and Meditech
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All data will be obtained from Epic and Meditech
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All data will be collected retrospectively after the patient is discharged from the hospital
Study Design
Outcome Measures
Primary Outcome Measures
- Incidence of C. Difficile infection (CDI) within one year post-transplant [April 1, 2014 to July 31, 2019]
Incidence of C. Difficile infection within one year post-transplant for CDI post-transplant.
- Risk factors for CDI post-transplant - No.1 [April 1, 2014 to July 31, 2019]
Risk factors transplanted organ
- Risk factors for CDI post-transplant - No.2 [April 1, 2014 to July 31, 2019]
Origin of transplanted graft including age of donor
- Risk factors for CDI post-transplant No.-3 [April 1, 2014 to July 31, 2019]
Induction agent used
- Risk factors for CDI post-transplant No.4 [April 1, 2014 to July 31, 2019]
Acid suppression
- Risk factors for CDI post-transplant No.5 [April 1, 2014 to July 31, 2019]
First time SOT recipient
- Risk factors for CDI post-transplant No.6 [April 1, 2014 to July 31, 2019]
History of CDI in the year prior to transplant
- Risk factors for CDI post-transplant No.7 [April 1, 2014 to July 31, 2019]
Co-infection with HIV/AIDS
- Risk factors for CDI post-transplant No.8 [April 1, 2014 to July 31, 2019]
Length of hospital stay
- Risk factors for CDI post-transplant No. 9 [April 1, 2014 to July 31, 2019]
Length of intensive care unit stay
- Risk factors for CDI post-transplant No.10 [April 1, 2014 to July 31, 2019]
Intra-operative administration of blood products
- Risk factors for CDI post-transplant No. 11 [April 1, 2014 to July 31, 2019]
Antibiotic use in the 90 days prior to infection
- Risk factors for CDI post-transplant No. 12 [April 1, 2014 to July 31, 2019]
Antibiotic use in the 90 days post-transplant
- Risk factors for CDI post-transplant No, 13 [April 1, 2014 to July 31, 2019]
Hospitalization in the 90 days prior to transplantation
- Risk factors for CDI post-transplant No, 14 [April 1, 2014 to July 31, 2019]
Hospitalization in the 90 days post-transplant
Eligibility Criteria
Criteria
Inclusion Criteria:
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Solid organ transplant patients who received graft(s) at MDMC from April 1, 2015 to July 31, 2018
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Age >18 years old
Exclusion Criteria:
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Age <18 years old
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Loss to early death defined as within one week from transplantation
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Patients whose primary address is in Puerto Rico
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Jessica Rago | Dallas | Texas | United States | 75247 |
Sponsors and Collaborators
- Methodist Health System
Investigators
- Principal Investigator: Jessica Crotty, PharmD, Methodist Dallas Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 059.PHA.2019.D