Incidence and Risk Factors for Developing Infections in Patients Colonized by CP-KPC
Study Details
Study Description
Brief Summary
The worldwide increase in the rate of infections due to multidrug-resistant bacteria is considered a major public health problem.
Infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-KP) are associated with high morbidity and mortality. Mortality of up to 70% and, in survivors, a readmission rate of up to 72% within 90 days of discharge have been reported.
CR-KP infection is usually preceded by colonization. However, the incidence rate and risk factors for CR-KP infections among carriers is poorly understood.
Multiple studies have focused in risk factors to develop infections among carriers.
In order to identify patients at low risk of CR-KP bloodstream infections, Gianella et at developed a predictive score to stratify patients according to their risk for acquisition of CR-KP infections.
However, further studies are needed to validate these results, particularly in high-risk patients, such as haematological patients, solid organ trasplant recipients and patients admitted in ICU.
Italian Hospital is an acute tertiary care university teaching hospital with more than 45,000 admission-years, in Buenos Aires, Argentina, with a great proportion of haematological and solid organ transplant recipients, and patients with substantial comorbidities and immunosuppression.
With the aim of developing an adequate risk assessment for CR-KP infections among CR-KP carriers, we performed a retrospective cohort analysis, in a tertiary teaching hospital in Buenos Aires, Argentina.
The main purpose of our study is to describe the incidence of CR-KP infections among CRKP colonized patients, to demonstrate the risk factors for acquisition of CR-KP infections and to develop a clinical predictive score that could stratify patients to guide therapeutic decisions in CR-KP carriers, and avoid overuse of broad-spectrum therapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- CRKP infections in CRKP colonized patients [through study completion, an average of 1 year]
the presence of a positive clinical culture of CR-KP, a documented physician diagnosis, and the initiation of targeted antimicrobial therapy.
Secondary Outcome Measures
- 30 day all-cause mortality [through study completion, an average of 1 year]
30-day mortality rate starting from the date the relevant clinical culture was obtained.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Adult (≥18 years) patients with a CR-KP positive rectal swab, hospitalized from 01/2014 to 01/2019
Exclusion Criteria:
- Unwillingness to participate
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Italiano de Buenos Aires | Ciudad Autonoma de Buenos Aire | Ciudad Autonoma De Buenos Aires | Argentina | 1181 |
Sponsors and Collaborators
- Hospital Italiano de Buenos Aires
Investigators
- Principal Investigator: Marina Valinoti, MD, Hospital Italiano de Buenos Aires
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 3978