Protein Requirements In Active Female Populations

Sponsor

University of Toronto (Other)

Overall Status

Completed

CT.gov ID

NCT02626429

Collaborator

Ajinomoto Co., Inc. (Industry)

Enrollment

Arm

Actual Duration (Months)

Study Details

Study Description

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in active, young adult females using the IAAO technique in the presence of a variable intensity exercise stimulus.

Condition or Disease	Intervention/Treatment	Phase
Increased Metabolic Requirement Healthy	Dietary Supplement: Amino acid intake	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

6 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Evaluation of Protein Requirements in Active, Young Adult Females

Actual Study Start Date :

May 1, 2015

Actual Primary Completion Date :

Jun 1, 2017

Actual Study Completion Date :

Jun 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Active, Young Adult Famale Participants will complete a bout of exercise and then consume a randomly assigned amino acid intake prior to measuring whole body 13CO2 excretion and phenylalanine oxidation.	Dietary Supplement: Amino acid intake Amino acid intakes will be varied at 0.2-2.6 g/kg/day

Arm

Intervention/Treatment

Experimental: Active, Young Adult Famale

Participants will complete a bout of exercise and then consume a randomly assigned amino acid intake prior to measuring whole body 13CO2 excretion and phenylalanine oxidation.

Dietary Supplement: Amino acid intake

Amino acid intakes will be varied at 0.2-2.6 g/kg/day

Outcome Measures

Primary Outcome Measures

13CO2 (carbon dioxide) excretion (μmol/kg/h) [4 hours / study day]

Secondary Outcome Measures

13C-Phenylalanine Oxidation (μmol/kg/h) [4 hours / study day]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 35 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy, active, young adult females who regularly participate in moderate-vigorous activity 5x per week, for a minimum of 1 hour
A minimum score of 10 on the Beep Test (a measure of aerobic fitness)

Exclusion Criteria:

Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
Regular tobacco use
Illicit drug use

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

University of Toronto
Ajinomoto Co., Inc.

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Daniel Moore, Assistant professaor, University of Toronto

ClinicalTrials.gov Identifier:

NCT02626429

Other Study ID Numbers:

IAAO-YF

First Posted:

Dec 10, 2015

Last Update Posted:

Dec 11, 2017

Last Verified:

Dec 1, 2017

Study Results

No Results Posted as of Dec 11, 2017