EP: Protein Requirements in Endurance-trained Athlete

Sponsor

University of Toronto (Other)

Overall Status

Completed

CT.gov ID

NCT02478801

Collaborator

Ajinomoto Co., Inc. (Industry)

Enrollment

Arm

Duration (Months)

Study Details

Study Description

Brief Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data.

Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

Condition or Disease	Intervention/Treatment	Phase
Increased Metabolic Requirement Healthy	Dietary Supplement: amino acids intake	Early Phase 1

Study Design

Study Type:

Interventional

Actual Enrollment :

9 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Evaluation of Protein Requirements in Male Endurance Athletes

Study Start Date :

Mar 1, 2015

Actual Primary Completion Date :

Jan 1, 2016

Actual Study Completion Date :

May 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Endurance trained subjects will receive different levels of amino acids intakes varying from 0.2 to 2.8 g/kg/day.	Dietary Supplement: amino acids intake amino acids intakes will be varied at 0.2-2.8 g/kg/day

Arm

Intervention/Treatment

Experimental: Endurance trained

subjects will receive different levels of amino acids intakes varying from 0.2 to 2.8 g/kg/day.

Dietary Supplement: amino acids intake

amino acids intakes will be varied at 0.2-2.8 g/kg/day

Outcome Measures

Primary Outcome Measures

13CO2 (carbon dioxide) excretion (μmol/kg/h) [4 hours / study day]

Secondary Outcome Measures

[13C]phenylalanine oxidation (μmol/kg/h) [4 hours/study day]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 35 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy, male, endurance-trained participants who regularly more than 40 km/week
Ability to perform the exercise stimulus (20 km run) on metabolic trial.

Exclusion Criteria:

Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
Regular tobacco use
Illicit drug use

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

University of Toronto
Ajinomoto Co., Inc.

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Daniel Moore, Assistant Professor, University of Toronto

ClinicalTrials.gov Identifier:

NCT02478801

Other Study ID Numbers:

IAAO-E

First Posted:

Jun 23, 2015

Last Update Posted:

Jun 16, 2016

Last Verified:

Jun 1, 2016

Study Results

No Results Posted as of Jun 16, 2016