IAAO-AF: Protein Requirements for Active Adolescent Females

• Sponsor: University of Toronto (Other)
• Overall Status: Completed
• CT.gov ID: NCT02800239
• Collaborator: Ajinomoto Co., Inc. (Industry)
• Enrollment: 7
• Location: 1
• Arm: 1
• Actual Duration (Months): 23
• Patients Per Site Per Month: 0.3

Study Details

Study Description

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in adolescent, females using the IAAO technique in the presence of a variable intensity exercise stimulus.

Condition or Disease	Intervention/Treatment	Phase
Increased Metabolic Requirement; Healthy	Dietary Supplement: Amino Acid Intake	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 7 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Evaluation of Protein Requirements in Active Adolescent Females
• Actual Study Start Date: Feb 1, 2016
• Actual Primary Completion Date: Oct 1, 2017
• Actual Study Completion Date: Dec 31, 2017

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Active, adolescent females Subjects will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d	Dietary Supplement: Amino Acid Intake; Amino acid intakes will be varied at 0.2-2.67 g/kg/d

Outcome Measures

Primary Outcome Measures

1. 13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h) [4 hours/ study day]

Secondary Outcome Measures

1. [13C]Phenylalanine Oxidation (µmol/kg/h) [4 hours/ study day]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 10 Years to 15 Years
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: Yes

Inclusion Criteria (Adolescents):

• Healthy, active adolescent who regularly participates in moderate to vigorous physical activity 5 times a week for a minimum of 1 hour.

• Being -0.5 to +1.0 years from peak height velocity, determined by the ratio of standing to sitting height, with the maximal age for adolescents being 16 years.

Obtaining a minimum level of 5.8 on the Beep Test

Exclusion Criteria (All Subjects):

• Inability to meet health and physical activity guidelines according to the Physical Activity Readiness Questionnaire (PAR-Q+) and Physical Activity Questionnaire,

• An inability to adhere to any of the protocol guidelines (i.e. caffeine consumption)

• A biological age falling outside of the aforementioned ranges

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Goldring Centre for High Performance Sport	Toronto	Ontario	Canada	M5S2C9

Sponsors and Collaborators

• University of Toronto
• Ajinomoto Co., Inc.

Investigators

• Principal Investigator: Daniel Moore, PhD, University of Toronto

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Daniel Moore, Assistant Professor, University of Toronto
• ClinicalTrials.gov Identifier: NCT02800239
• Other Study ID Numbers: IAAO-AF
• First Posted: Jun 15, 2016
• Last Update Posted: Apr 1, 2019
• Last Verified: Mar 1, 2019

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No

Study Results

No Results Posted as of Apr 1, 2019