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Indocyangreen Elimination in Cirrhosis and Acute Liver Failure

Sponsor
Heidelberg University (Other)
Overall Status
Completed
CT.gov ID
NCT00245310
Collaborator
(none)
40
Enrollment
1
Location
60
Duration (Months)
0.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Indocyangreen (ICG)is totally biliary eliminated and corresponds to hepatocyte function and liver perfusion.

The ICG-clearance will be evaluated as a prognostic marker in liver disease.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Indocyangreen (ICG) clearance

Detailed Description

patients with acute liver failure or advanced liver disease will be studied. ICG-clearance will be correlated with established clinical scores and outcome.

Study Design

Study Type:
Observational
Anticipated Enrollment :
40 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Evaluation of the Indocyangreen Elimination as a Prognostic Marker in Decompensated Cirrhosis and Acute Liver Failure
Study Start Date :
Oct 1, 2005
Actual Primary Completion Date :
Oct 1, 2010
Actual Study Completion Date :
Oct 1, 2010

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • acute liver failure OR end-stage liver disease

    • normal hepatic perfusion by doppler ultrasound

    Exclusion Criteria:

    • portal vein thrombosis

    • allergy to ICG or iodine

    • thyroid disease

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Heidelberg Heidelberg Germany 69120

    Sponsors and Collaborators

    • Heidelberg University

    Investigators

    • Principal Investigator: Jens Encke, PD Dr. med., Heidelberg University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00245310
    Other Study ID Numbers:
    • LiMON
    First Posted:
    Oct 27, 2005
    Last Update Posted:
    Oct 11, 2010
    Last Verified:
    Nov 1, 2008
    Keywords provided by , ,
    ICG clearance
    liver cirrhosis
    acute liver failure
    prognosis
    Additional relevant MeSH terms:
    Liver Cirrhosis
    Liver Failure
    Hepatic Insufficiency
    Liver Failure, Acute
    Fibrosis

    Study Results

    No Results Posted as of Oct 11, 2010