Comparison Between Different Ventilator Hyperinflation Maneuvers
Study Details
Study Description
Brief Summary
The hyperinflation ventilator was performed in different modalities and ventilatory adjustments, with total pressure of 40cmH2O. The inspiratory volume, inspiratory time, mean airway pressure, inspiratory and expiratory flow, and bias flow were evaluated.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
PURPOSE: To compare different ways of applying ventilator hyperinflation. METHODS: A randomized crossover clinical trial was performed with 30 patients (66.5 ± 17.3 years) with hypersecretion. The ventilator hyperinflation was performed in five ventilatory modalities for five minutes, with an interval of 2 hours, the order being determined by randomization: controlled ventilation at volume (VCV) with constant flow of 20 (VCV20) Lpm and 40 Lpm (VCV40), controlled ventilation pressure ventilation (PCV), controlled pressure ventilation associated with inspiratory time adjustment (PCV + Tins) and support pressure ventilation (PSV). In VCV mode, the volume was increased every 50mL, until reaching a maximum pressure of 40cmH2O. In the pressure controlled modes, the inspiratory pressure was increased every 5 cmH2O until the total pressure reached 40 cmH2O. The inspiratory time was adjusted so that the inspiratory flow reached the baseline. The following variables were evaluated: tidal volume, inspiratory time (Tins), mean airway pressure (Pmean), peak inspiratory flow (PIFR) and expiratory flow (PEFR), PIFR / PEFR and Bias Flow (PEFR-PIFR).
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: VCV20 Volume-controlled ventilation mode under constant flow of 20 Lpm. The inspired volume was progressively increased until the maximum pressure reached 40cmH2O. |
Other: VCV20
controlled volume ventilation mode under constant flow of 20 Lpm. The inspired volume was progressively increased until the Pmax reached 40cmH2O.
|
Experimental: VCV40 Volume controlled ventilation mode under constant flow of 40 Lpm. The inspired volume was progressively increased until the maximum pressure reached 40cmH2O. |
Other: VCV40
volume controlled ventilation mode under constant flow of 40 Lpm. The inspired volume was progressively increased until the Pmax reached 40cmH2O.
|
Experimental: PCV Pressure controlled ventilation mode, inspiratory time of 1 second. The inspiratory pressure was increased every 5 cmH2O, until reaching the maximum pressure of 40 cmH2O. |
Other: PCV
controlled ventilation mode, 1 second inspiratory time. The inspiratory pressure was increased every 5 cmH2O, until reaching the maximum pressure of 40 cmH2O.
|
Experimental: PCV+Tins Pressure controlled ventilation mode and inspiratory pressure was increased every 5cmH2O, until the maximum pressure of 40 cmH2O was reached. The inspiratory time was gradually increased until the inspiratory flow reached the baseline. Concomitantly, the respiratory rate was decreased to allow the expiratory flow also to reach the baseline, to avoid self-PEEP. |
Other: PCV+Tins
controlled ventilation and inspiratory pressure was increased every 5 cmH2O until the maximum pressure was 40 cmH2O. The inspiratory time was gradually increased until the inspiratory flow reached the baseline. Concomitantly, the respiratory rate was decreased to allow the expiratory flow also to reach the baseline, to avoid self-PEEP.
|
Experimental: PSV Pressure support ventilation mode, with progressive increases of 5 cmH2O at inspiratory pressure, until reaching Pmax of 40 cmH2O. The expiratory sensitivity was adjusted by 25% for all patients. |
Other: PSV
ventilatory mode with pressure support, with progressive increases of 5 cmH2O at inspiratory pressure, until reaching Pmax of 40 cmH2O. The expiratory sensitivity was adjusted by 25% for all patients.
|
Outcome Measures
Primary Outcome Measures
- Inspiratory Volume [Five minutes after the onset of intervention]
Inspiratory volume reached in each mode of ventilator hyperinflation, under a maximum pressure of 40cmH2O
- Inspiratory time [Five minutes after the onset of intervention]
inspiratory time necessary for the inspiratory flow to reach the baseline or according to the settings of each modality
- Mean Pressure [Five minutes after the onset of intervention]
airway mean pressure measured on the mechanical ventilator in 2 cycles
- Peak Expiratory Flow [Five minutes after the onset of intervention]
maximal expiratory flow in 2 cycles
- Peak Inspiratory Flow [Five minutes after the onset of intervention]
Maximal inspiratory flow in 2 cycles
- PIFR/PEFR [Five minutes after the onset of intervention]
Peak inspiratory to expiratory flow ratio
- Bias Flow [Five minutes after the onset of intervention]
Difference between peak inspiratory and expiratory flows
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Pulmonary infection
-
Mechanically ventilated for more than 96 hours through pressure-assisted ventilation (PSV) or pressure-controlled ventilation (PCV)
-
Static compliance between 30 and 70 mL/cmH2O
-
PEEP between 5 and 8 cmH2O.
Exclusion Criteria:
-
Hemodynamic instability
-
Non-drained pleural effusion or pneumothorax
-
Intracranial hypertension
-
Bronchospasm
-
Adult respiratory distress syndrome (ARDS)
-
Decompensated congestive heart failure
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Luciano M Chicayban | Campos Dos Goytacazes | RJ | Brazil | 28015150 |
Sponsors and Collaborators
- Brazilian Institute of Higher Education of Censa
Investigators
- Principal Investigator: LUCIANO M CHICAYBAN, MSc, Brazilian Institute of Higher Education of Censa
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- VHI Modality