Letrozole Versus Laparoscopic Ovarian Drilling in Polycystic Ovary Syndrome
Study Details
Study Description
Brief Summary
Polycystic ovary syndrome is the major cause of anovulatory infertility. Clomiphene citrate is the most commonly used oral agent for ovulation induction in this group, but there are some drawbacks with the use of it.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 3 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: letrozole letrozole 2.5 mg oral tablets will be started daily from day 3 of the menses for 5 days in a dose of 5 mg/day |
Drug: Letrozole
oral tablets 2.5 mg
Other Names:
|
Active Comparator: laparoscopic drilling laparoscopy will be performed using three-puncture technique. Each ovary will be cauterized at four points, each for 4 seconds at 40 W for a depth of 4 mm with a mixed current, using a monopolar electrosurgical needle |
Procedure: ovarian drilling
laparoscopic electrocauterization
|
Outcome Measures
Primary Outcome Measures
- The ovulation rate [3 months]
Secondary Outcome Measures
- The mid-cyclic endometrial thickness [one day]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
History of at least one year of infertility either primary or secondary.
-
Body mass index: 25-35
-
Normal fallopian tubes
-
Normal semen analysis of the husband
-
Women who will accept to participate in the study
Exclusion Criteria:
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Body mass index above 35
-
Contraindication to general anesthesia
-
Previous laparoscopic drilling
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Presence of other causes of infertility
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Women who had received metformin, gonadotrophin, oral contraceptives or other hormonal drugs during the preceding 6 months
-
Women who intended to start a diet program
-
Women who will refuse to participate in the study.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Assiut University | Assiut | Egypt |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- LEVOD