Dual Trigger Versus Booster Dose of HCG
Study Details
Study Description
Brief Summary
To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared dual trigger with GnRH agonist plus 1000 IU of HCG or triggering with GnRH and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Dual trigger GnRH agonist plus 1000 IU of HCG to trigger final maturation |
Procedure: IVF/ICSI
Drug: Human Chorionic Gonadotropin
given in different doses and timing to support the luteal phase
|
Active Comparator: Booster HCG dose GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup |
Procedure: IVF/ICSI
Drug: Human Chorionic Gonadotropin
given in different doses and timing to support the luteal phase
|
Outcome Measures
Primary Outcome Measures
- Clinical pregnancy rate [1 year]
The number of cycles with a evidence of a gestational sac with fetal pulstaions after 5 weeks from pregnancy test
Secondary Outcome Measures
- OHSS rate [1 year]
The number of cycles with evidence of OHSS
Other Outcome Measures
- Chemical pregnancy rate [1 year]
The numbr of cycles with a positive pregnancy test after 14 days from embryo transfer
- Early miscarriage rate [1 year]
Pregnancies ending with miscarriage before 12 weeks of gestation
- Ongoing pregnancy rate [1 year]
Pregnancies ongoing beyond 12 weeks of gestation
- Live birth rate [1 year]
Pregnancies ending in a live birth
Eligibility Criteria
Criteria
Inclusion Criteria:
-
High responder females undergoing antagonist protocol IVF/ICSI cycle
-
More than 14 MII oocytes
-
Estradiol more than 3500 pg/ml on day of trigger
Exclusion Criteria:
-
Any other protocol
-
Normal or poor responders
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini) | Cairo | Egypt | ||
2 | Adam International hospital | Giza | Egypt | ||
3 | Nile IVF center | Giza | Egypt |
Sponsors and Collaborators
- Cairo University
- Nile Ivf Center, Cairo, Egypt
- Adam International Hospital
Investigators
- Study Director: Sarwat Ahwany, MD, Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 12015