Freeze-all Policy in Poor Responders
Study Details
Study Description
Brief Summary
To compare the effects of fresh embryo transfers (ET) and elective frozen-thawed embryo transfer cycles in poor ovarian responders.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Freeze-all Good quality embryos (either day 3 or 5) will be frozen and subsequent frozen embryo transfer will be arranged within three months of the egg retrival. |
Other: Freeze-all policy
A policy of freezing all the embryos followed by subsequent thawed frozen embryo transfer
|
| No Intervention: Fresh embryo transfer Women will undergo fresh embryo transfer at the cleavage (day 3) or blastocyst stage (day 5). |
Outcome Measures
Primary Outcome Measures
- Livebirth rate [32 weeks]
The proportion of women in the population who had at least one live baby.
Secondary Outcome Measures
- Pregnancy rate [2 weeks]
Positive pregnancy test at two weeks +/- three days after embryo transfer
- Clinical pregnancy rate [6-8 weeks]
The presence of at least one fetal heartbeat at ultrasound between six and eight weeks of gestation
Eligibility Criteria
Criteria
Inclusion Criteria:
-
All patients that fulfill the Bologna criteria [at least 2 of the following 3 features must be present: (i) advanced maternal age or any other risk factor for POR; (ii) a previous POR; and (iii) an abnormal ovarian reserve test (ORT)]
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if the progesterone serum level was ≤1.5 ng/mL on the trigger day.
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body mass index 18-32 kg/m2
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Both partners are able to provide written informed consent.
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At least 1 good quality embryo on day 3 after egg collection on day 3 according to the Istanbul consensus (7-8 cells; with symmetric blastomeres and <10% fragmentation by volume).
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Endometrial thickness ≥8 mm on trigger day.
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a normal uterine cavity on ultrasound.
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IVF/ICSI with only fresh semen
Exclusion Criteria:
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Pre-implantation genetic testing is being planned.
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if they had severe endometriosis, uterine pathology (myomas, adenomyosis, endocrinopathies, adhesions, acquired or congenital abnormalities), untreated tubal hydrosalpinges, ovarian tumor, recurrent spontaneous abortion, implantation failure after ≥ 2 fresh or frozen ET.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Al-Yasmeen Fertility and Gynecology Center | Banhā | Egypt |
Sponsors and Collaborators
- Al-Yasmeen Fertility and Gynecology Center
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- #0014