the Effect of Endometrial Compaction Caused by Progesterone Effect on Pregnancy Outcomes
Study Details
Study Description
Brief Summary
The purpose of this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
For a pregnancy to occur, the embryo must implant in a receptive endometrium during the window of implantation, which is thought to occur from day 22 to 24 of an idealized 28-day cycle. Early studies have suggested that assessing endometrial thickness with the use of ultrasound may be an alternative to invasive techniques such as endometrial biopsy for attempting to determine a receptive endometrium for frozen-thawed embryo transfer (FET).
A preovulatory endometrial thickness of 7 mm or more is considered to be the cutoff for endometrial receptivity, below which many physicians would cancel an embryo transfer. However, in most studies in the literature, endometrial thickness was measured either on the day of hCG in fresh embryo transfer cases or on the last day of estrogen treatment in thawed embryo transfers. There are a limited number of studies evaluating the luteal period, embryo transfer day and endometrial thickness.
Accordingly, in this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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with endometrial compaction Participants who have endometrial compaction caused by progesterone effects on undergoing frozen embryo transfer with artificial hormone replacement |
Drug: Progesterone
ultrasound measurements of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.
Other Names:
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without endometrial compaction Participants who have not endometrial compaction caused by progesterone effects on undergoing frozen embryo transfer with artificial hormone replacement |
Drug: Progesterone
ultrasound measurements of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.
Other Names:
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Outcome Measures
Primary Outcome Measures
- The change in millimeters endometrial thickness and ongoing pregnancy rates. [18 months]
changing in millimeters of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.
Secondary Outcome Measures
- The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer [On the day of frozen embryo transfer]
comparison of progesterone levels and endometrial thickness
- Clinical pregnancy rate [6-7 weeks after the last menstrual period of the patient]
6th week gestational age
- Implantation rate [5 weeks after the last menstrual period of the patient]
Percentage of gestational sacs compared to the number of embryos transferred
- Clinical miscarriage [after 5th gestational week]
pregnancy loss after ultrasonographic detection of an intrauterine gestational sac
Eligibility Criteria
Criteria
Inclusion Criteria:
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Woman aged 18-40 years
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Presence of high quality (>2BB) blastocyst
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Hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles
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presence of high quality blastocyst cryopreserved by vitrification method.
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A single embryo transfer
Exclusion Criteria:
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Presence of uterine pathology
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Participants whose optimal endometrial image cannot be obtained due to uterine position
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Participants whose treatments were canceled for any reason before embryo transfer
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Participants which had embryo transfer on the day 2 or 3 (at the cleavage stage)
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Participants who had 2 embryo transfer
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Presence of low quality (<2BB) blastocyst
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15% loss of viability in the embryo during embryo thawing
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Akdeniz University | Antalya | Turkey |
Sponsors and Collaborators
- Akdeniz University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AkdenizUKD