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Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

Sponsor
National Cheng-Kung University Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT04275674
Collaborator
(none)
57
Enrollment
1
Location
71
Anticipated Duration (Months)
0.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation. Obesity is associated with an increased risk of recurrent miscarriage (RM), but the underlying mechanisms are unclear. Abnormal inflammasome activation was also identified in the endometrium of women who experienced RM. Given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and RM, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    pending

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    57 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Dr. Pao-Lin Kuo (Department of Obstetrics and Gynecology
    Actual Study Start Date :
    Aug 1, 2017
    Anticipated Primary Completion Date :
    Jul 1, 2023
    Anticipated Study Completion Date :
    Jul 1, 2023

    Outcome Measures

    Primary Outcome Measures

    1. Validity of inflammatory markers [1 Day]

      Use the levels of hsCRP and CA125 provides the information about inflammation.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 50 Years
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    All women have conceived naturally without the aid of assisted reproductive technologies

    Exclusion Criteria:

    N/A

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Cheng-Kung University Hospital Tainan Taiwan 70428

    Sponsors and Collaborators

    • National Cheng-Kung University Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cheng-Kung University Hospital
    ClinicalTrials.gov Identifier:
    NCT04275674
    Other Study ID Numbers:
    • A-ER-105-481
    First Posted:
    Feb 19, 2020
    Last Update Posted:
    Sep 24, 2020
    Last Verified:
    Sep 1, 2020
    Additional relevant MeSH terms:
    Inflammation

    Study Results

    No Results Posted as of Sep 24, 2020