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The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

Sponsor
University of Cologne (Other)
Overall Status
Completed
CT.gov ID
NCT01115218
Collaborator
(none)
62
Enrollment
1
Location
29
Actual Duration (Months)
2.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Trabeculectomy

Study Design

Study Type:
Observational
Actual Enrollment :
62 participants
Observational Model:
Case-Only
Time Perspective:
Prospective
Official Title:
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy
Actual Study Start Date :
Oct 1, 2009
Actual Primary Completion Date :
Jan 1, 2010
Actual Study Completion Date :
Mar 1, 2012

Arms and Interventions

Arm Intervention/Treatment
Glaucoma patients

Procedure: Trabeculectomy
Trabeculectomy with mitomycin C

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • patients with glaucoma with a trabeculectomy required

    • 60 eyes of 60 patients, The ratio of female / male is not involved.

    • Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).

    • age of at least 18 years

    Exclusion Criteria:

    • all patients not included in the group of inclusion criteria.

    • less than 50yl anterior chamber fluid could be collected during the operation.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University Eye Hospital, University of Cologne Cologne NRW Germany 50937

    Sponsors and Collaborators

    • University of Cologne

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Arno Hueber, Arno Hueber, University of Cologne
    ClinicalTrials.gov Identifier:
    NCT01115218
    Other Study ID Numbers:
    • MeVeTra-2009
    First Posted:
    May 4, 2010
    Last Update Posted:
    Nov 20, 2018
    Last Verified:
    Nov 1, 2018
    Keywords provided by Arno Hueber, Arno Hueber, University of Cologne
    Glaucoma
    Additional relevant MeSH terms:
    Glaucoma

    Study Results

    No Results Posted as of Nov 20, 2018