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Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

Sponsor
Universitätsmedizin Mannheim (Other)
Overall Status
Completed
CT.gov ID
NCT01762917
Collaborator
(none)
45
Enrollment
1
Location
39
Duration (Months)
1.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    45 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Influence of Bag Volume Variation in Inert Gas Rebreathing Pulmonary Blood Flow Measurements on the Reproducibility in Patients With Pulmonary Diseases
    Study Start Date :
    Sep 1, 2007
    Actual Primary Completion Date :
    Dec 1, 2010
    Actual Study Completion Date :
    Dec 1, 2010

    Arms and Interventions

    Arm Intervention/Treatment
    Obstruction

    Patients suffering from pulmonary obstruction
    Restriction

    Patients suffering from pulmonary restriction
    Controls

    Pulmonary healthy controls

    Outcome Measures

    Primary Outcome Measures

    1. pulmonary blood flow [1 day]

      variation of serial pulmonary blood flow measurements

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 90 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • ability to perform rebreathing maneuver
    Exclusion Criteria:

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University Hospital Mannheim Mannheim Germany

    Sponsors and Collaborators

    • Universitätsmedizin Mannheim

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Joachim Saur, Principal Investigator, Universitätsmedizin Mannheim
    ClinicalTrials.gov Identifier:
    NCT01762917
    Other Study ID Numbers:
    • IGR_Vbag_MA
    First Posted:
    Jan 8, 2013
    Last Update Posted:
    Jan 8, 2013
    Last Verified:
    Jan 1, 2013
    Additional relevant MeSH terms:
    Lung Diseases
    Lung Diseases, Obstructive
    Pulmonary Disease, Chronic Obstructive
    Asthma

    Study Results

    No Results Posted as of Jan 8, 2013