Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) and Delirium in Geriatric Patients

Sponsor

Aarhus University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT03175276

Collaborator

University of Aarhus (Other)

315

Enrollment

Location

10.4

Actual Duration (Months)

30.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To investigate the usefulness of the Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) to predict delirium in elderly patients admitted to Emergency Department (ED) with geriatric assessment and transferred to Geriatric ward.

Condition or Disease	Intervention/Treatment	Phase
Delirium in Old Age Cognitive Decline

Detailed Description

Design: The project will be conducted as a prospective study.

Methods:

Exposure: The short IQCODE is a 16-item questionnaire that ask relatives about changes in the elderly patients cognitive performance over the previous 10 years. The score range from one to five, with a high score reflecting bad evolution through the years.

Settings: Patients (aged ≥75 years) admitted to ED (medical and surgery) and transferred to a geriatric ward at Aarhus University Hospital, who meet the inclusion criteria will be asked if the staff is allowed to contact their relatives. By oral consent, the relatives are interviewed by telephone or at the hospital. The IQCODE are filled in during the interview.

In the geriatric ward the assessment of delirium by a positive Confusion Assesment Method (CAM) is done twice a day and is part of the regular procedure in the Geriatric Department at Aarhus University Hospital.

Sample size: The power calculation is based on a pilot study of IQCODE. The study that included 32 75-year-olds from geriatric ward at Aarhus University hospital, showed an no incidence of delirium of when the IQCODE-score was ≤3,125. On the contrary the incidence of delirium was 15% when the IQCODE-score was >3,125. With a power of 90% and a significance level of 5%, 76 patients should be included in each group to predict delirium.

Time frame: Of the 80 admitted to the geriatric wards, only 20% in the pilot study had an IQCODE-score ≤3,125. With an expected response rate of 70%, the data collection period is expected to last five months.

Study Design

Study Type:

Observational

Actual Enrollment :

315 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Predict IQCODE Delirium in Geriatric Patients

Actual Study Start Date :

Mar 20, 2017

Actual Primary Completion Date :

Jan 31, 2018

Actual Study Completion Date :

Jan 31, 2018

Outcome Measures

Primary Outcome Measures

Delirium [Repeated measurements twice a day at 7-11 AM and 5-10 PM until discharge]
Delirium diagnosed using the Confusion Assessment Method (CAM) - Danish version. Incidence of delirium is measured by the first positive CAM score.

Eligibility Criteria

Criteria

Ages Eligible for Study:

75 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients admitted to the emergency medical and surgery ward and transferred to a geriatric ward at Aarhus University Hospital in the period from the 20th of March to September 2017.

Exclusion Criteria:

Patients transferred to the geriatric ward in the evening and night as well as weekends and holidays, when there is no Geriatric staff present.
Patients who upon admission are dying assessed by a geriatrician
Patients with stroke where aphasia is present
Patients with severe dementia without language
Patients who are inability to understand or speak Danish

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Aarhus University hospital	Aarhus	Central Danmark Region	Denmark	8200

Sponsors and Collaborators

Aarhus University Hospital
University of Aarhus

Investigators

Study Chair: Else Marie Damsgaard, Professor, Department of Geriatrics , Aarhus University Hospital Palle Juul-Jensens Boulevard 99, Building J, J513, DK-8200 Aarhus N