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Inhibitory Receptors in Eosinophils of Atopic Subjects

Sponsor
Meir Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT01489293
Collaborator
(none)
40
Enrollment
1
Location
20
Actual Duration (Months)
2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to analyze the expression and activity of inhibitory molecules on eosinophils obtained from allergic subjects.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    40 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Other
    Official Title:
    Characterization of the Expression and Activity of Inhibitory Receptors Such as CLM-1 in Eosinophils of Atopic Subjects
    Actual Study Start Date :
    May 1, 2012
    Actual Primary Completion Date :
    Dec 31, 2013
    Actual Study Completion Date :
    Dec 31, 2013

    Arms and Interventions

    Arm Intervention/Treatment
    atopic subjects

    Patients with one atopic disease or more (atopic dermatitis,rhinitis, asthma, food allergy)
    non-atopic subjects

    Control group without atopic diseases.

    Outcome Measures

    Primary Outcome Measures

    1. Expression of surface molecules on eosinophils as assessed by flow cytometry [December 2013]

      Blood samples from donors will be stained and evaluated by flow cytomtery

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 60 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • age 20-60 years

    • a physician-diagnosed atopic disease

    Exclusion Criteria:

    • atopic disease not active

    • steroid treatment

    • active non-atopic inflammatory disease, including infections

    • pregnancy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Meir Medical Center. Unit of Allergy and Clinical Immunology Kfar Saba Israel

    Sponsors and Collaborators

    • Meir Medical Center

    Investigators

    • Principal Investigator: Alon Y Hershko, MD, PhD, Meir Medical Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Meir Medical Center
    ClinicalTrials.gov Identifier:
    NCT01489293
    Other Study ID Numbers:
    • MMC110053CTIL
    First Posted:
    Dec 9, 2011
    Last Update Posted:
    Mar 22, 2018
    Last Verified:
    Mar 1, 2018
    Additional relevant MeSH terms:
    Rhinitis
    Rhinitis, Allergic
    Dermatitis, Atopic
    Dermatitis
    Food Hypersensitivity

    Study Results

    No Results Posted as of Mar 22, 2018