Effect of Different Protein Diets on Glucose and Insulin Metabolism and Substrate Partitioning

• Sponsor: Maastricht University Medical Center (Other)
• Overall Status: Completed
• CT.gov ID: NCT01034241
• Collaborator: Nederlandse Zuivel Organisatie (Other)
• Enrollment: 12
• Arms: 4
• Duration (Months): 11

Study Details

Study Description

Brief Summary

The purpose of this study is to determine whether different protein diets affects glucose and insulin metabolism and substrate partitioning.

Condition or Disease	Intervention/Treatment	Phase
Insulin; Glucose Metabolism	Dietary Supplement: Control; Dietary Supplement: High dairy protein; Dietary Supplement: vegetable protein; Dietary Supplement: High GI	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 12 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Single (Participant)
• Primary Purpose: Prevention
• Official Title: Effect of Different Protein Diets on Glucose and Insulin Metabolism and Substrate Partitioning
• Study Start Date: Apr 1, 2009
• Actual Primary Completion Date: Jan 1, 2010
• Actual Study Completion Date: Mar 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Control Diet consists of 15% dairy protein and low Glycemic Index (GI < 40), 55 En% carbohydrates and 30 En% fat	Dietary Supplement: Control; Diet consists of 15 En% dairy protein and low GI, 55 En% carbohydrates and 30 En% fat
Experimental: High dairy protein Diet consists of 25% dairy protein and low GI (GI < 40), 45 En% carbohydrates and 30 En% fat	Dietary Supplement: High dairy protein; Diet consists of 25 En% dairy protein and low GI, 55 En% carbohydrates and 30 En% fat
Experimental: vegetable protein Diet consists of 15 En% vegetable protein and low GI (GI < 40), 55 En% carbohydrates and 30 En% fat	Dietary Supplement: vegetable protein; Diet consists of 15 En% vegetable protein and low GI, 55 En% carbohydrates and 30 En% fat
Experimental: High GI Diet consists of 15 En% dairy protein and high GI(GI > 60, 55 En% carbohydrates and 30 En% fat	Dietary Supplement: High GI; Diet consists of 15 En% dairy protein and high GI, 55 En% carbohydrates and 30 En% fat

Outcome Measures

Primary Outcome Measures

1. Glucose and insulin metabolism (24 h) [24 h]

Secondary Outcome Measures

1. Substrate partitioning and metabolic markers [24 h]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 35 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• BMI: 18.5-25 kg/m2 (lean)

• Gender: Male

• Age: <35 years

• Caucasian

Exclusion Criteria:

• Elevated fasting blood glucose level

• Lactose intolerant

• Diabetes Mellitus

• Hypertension (systolic/diastolic blood pressure)

• Hypotension (systolic/diastolic blood pressure)

• Cardiovascular diseases

• Asthma and other obstructive pulmonary diseases

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Maastricht University Medical Center
• Nederlandse Zuivel Organisatie

Investigators

• Principal Investigator: Wim Saris, Prof. Dr., Maastricht University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Maastricht University Medical Center
• ClinicalTrials.gov Identifier: NCT01034241
• Other Study ID Numbers: MEC 08-3-072
• First Posted: Dec 17, 2009
• Last Update Posted: Aug 23, 2018
• Last Verified: Aug 1, 2018

• Keywords provided by Maastricht University Medical Center: milk protein; overweight; insulin metabolism; substrate partitioning

Study Results

No Results Posted as of Aug 23, 2018