Metabolic Effects of Sleep Extension in People With Obesity
Study Details
Study Description
Brief Summary
This study is designed to determine the impact of extending sleep duration on glucose metabolism in people with obesity. Half of the participants will be instructed to increase their time-in-bed to 8 hours (sleep extension) while the other half will be be instructed to maintain their current sleep habits.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Restricting sleep is known to be detrimental to glucose metabolism in healthy adults. Obesity is a condition associated with both lower sleep duration and poor glucose tolerance. Therefore, increasing sleep duration is a potentially novel therapeutic strategy for improving glucose metabolism in this population. The investigators will assess this by determining insulin sensitivity during a hyperinsulinemic-euglycemic clamp before and after a sleep extension intervention in both the control and sleep extension groups.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No Intervention: Control Normal sleep habits < 6h |
|
| Experimental: Sleep Extension Extend time-in-bed to 8 hours |
Behavioral: Sleep extension
Extend time-in-bed to 8 hours
|
Outcome Measures
Primary Outcome Measures
- Insulin Sensitivity [Change from baseline testing after 4-6 weeks of intervention]
Whole-body insulin sensitivity during a hyperinsulinemic-euglycemic clamp
Secondary Outcome Measures
- 24 hour metabolite concentrations [Change from baseline testing after 4-6 weeks of intervention]
Plasma metabolite concentrations will be evaluated over a 24 hour period
- 24 hour hormone concentrations [Change from baseline testing after 4-6 weeks of intervention]
Plasma hormone concentrations will be evaluated over a 24 hour period
- 24 hour cytokine concentrations [Change from baseline testing after 4-6 weeks of intervention]
Plasma cytokine concentrations will be evaluated over a 24 hour period
- regulation of circadian rhythm [Change from baseline testing after 4-6 weeks of intervention]
Expression of peripheral clock genes
- Body composition [Change from baseline testing after 4-6 weeks of intervention]
Body composition will be assessed using dual-energy x-ray absorptiometry (DXA) and magnetic resonance scanning
- Sleep study [Change from baseline testing after 4-6 weeks of intervention]
Sleep staging will be assessed during an inpatient sleep study
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Sleep <6h/night
-
Body mass index 30-45 kg/m2
-
Altered glucose metabolism (any of the following) Fasting glucose ≥100 mg/dL or, 2-h plasma glucose ≥140 mg/dL during an oral glucose tolerance test (OGTT) or, HbA1c ≥5.7% or, homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.5
Exclusion Criteria:
-
Sleep disorders
-
Excessive caffeine or alcohol consumption
-
Significant organ dysfunction/disease (e.g. diabetes, kidney disease)
-
Prior bariatric surgery
-
Pregnancy
-
Tobacco or illicit drug use
-
Perform regular moderate or intense exercise
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
Sponsors and Collaborators
- Washington University School of Medicine
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 201805183