Effects of Supplementation With Linseed Oil on Blood Lipids in Vegetarians

• Sponsor: University of Jena (Other)
• Overall Status: Completed
• CT.gov ID: NCT01788917
• Collaborator: (none)
• Enrollment: 10
• Arm: 1
• Duration (Months): 3

Study Details

Study Description

Brief Summary

The study was performed to investigate the effects of a daily consumption of linseed oil on fatty acid distribution in plasma and red blood cell lipids and blood lipids in vegetarians.

Condition or Disease	Intervention/Treatment	Phase
Inter-conversion n-3 PUFA, Vegetarians	Dietary Supplement: linseed oil	N/A

Detailed Description

Recent studies suggest that the daily intake of n-3 LC-PUFA (EPA and DHA) can modulate cardiovascular risk factors and prevent lifestyle diseases.

The major dietary source of EPA and DHA is seafood (seaweeds and fatty cold water fishes), but they can also be found in lean red meat, in organ meats such as liver and brain. Vegetarians who do not eat meat or fish, have very low or negligible intakes of EPA (< 5 mg EPA/d) and DHA.

The purpose of the present study is to explore the tissue distribution and inter-conversion of ALA to n-3 LC-PUFA as consequence of linseed oil supplementation in vegetarians.

Eight vegetarians (3 m; 5 f) who do not eat meat, fish or seaweeds such as algae foods since least two years ago and two subjects (1 m; 1w) who consume the normal western style diet living in Jena (Germany) entered the study. The participants consumed 10 mL linseed oil per day for 10 weeks. The resulting daily dose of ALA was approx. 5.7 g/d.

Study Design

• Study Type: Interventional
• Actual Enrollment: 10 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Effects of Supplementation With Linseed Oil on Blood Lipids and Fatty Acid Profile in Plasma and Erythrocyte Lipids in Vegetarians
• Study Start Date: Sep 1, 2009
• Actual Primary Completion Date: Nov 1, 2009
• Actual Study Completion Date: Dec 1, 2009

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: linseed oil	Dietary Supplement: linseed oil; 10 ml linseed oil per day over 10 weeks (without control oil)

Outcome Measures

Primary Outcome Measures

1. EPA concentrations in plasma lipids and red blood cell lipids [10 weeks]

Secondary Outcome Measures

1. blood lipids [10 weeks]

   total cholesterol, triacylglycerides, high density cholesterol, low density cholesterol, lipoprotein a

Other Outcome Measures

1. parameters of iron status [10 weeks]

   transferrin, ferritin, transferrin saturation, total ferritin

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 30 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• for the vegetarian sub-group : vegetarian diet pattern

Exclusion Criteria:

• high performance sport, daily alcohol intake and the in-take of dietary supplements (e.g., fish oil capsules)

• for the vegetarian sub-group, the consumption of fish and algae products (e.g. seaweeds, sushi)

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• University of Jena

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Gerhard Jahreis, Professor Dr. G. Jahreis, University of Jena
• ClinicalTrials.gov Identifier: NCT01788917
• Other Study ID Numbers: H39_09
• First Posted: Feb 11, 2013
• Last Update Posted: Feb 11, 2013
• Last Verified: Feb 1, 2013

• Keywords provided by Gerhard Jahreis, Professor Dr. G. Jahreis, University of Jena: n-3 LC-PUFA, vegetarians, fatty acids, blood lipids

Study Results

No Results Posted as of Feb 11, 2013