A Study on the Inter-Hemispheric Alpha Ratio in Kids With ADHD (SHARK)

Sponsor

Radboud University Medical Center (Other)

Overall Status

Completed

CT.gov ID

NCT01932398

Collaborator

(none)

Enrollment

Location

Duration (Months)

1.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Investigate the hypothesis that children with ADHD have difficulty with the allocation of visio-spatial attention related to an inability to control posterior alpha brain oscillations. A paradigm will be used in which the aim is to address covert attention as similar recent studies did in adults with ADHD.

Condition or Disease	Intervention/Treatment	Phase
ADHD

Study Design

Study Type:

Observational

Actual Enrollment :

60 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Posterior Alpha Oscillations as an Index for the Attentional Bias in Children With Attentional Deficit Hyperactivity Disorder

Study Start Date :

Nov 1, 2011

Actual Primary Completion Date :

Jan 1, 2015

Actual Study Completion Date :

Jan 1, 2015

Arms and Interventions

Arm	Intervention/Treatment
ADHD A diagnosis of ADHD, classified by the DSM-IV.
no ADHD No diagnosis of ADHD, classified by the DSM-IV.

Outcome Measures

Primary Outcome Measures

Modualtion of alpha power [Once for half an hour]
Modulation* of alpha power on congruent and incongruent trials of the covert attention task in 30 ADHD children and in 30 non-ADHD children *Modulation is the (expected) cue-induced change by a covert attention task.

Secondary Outcome Measures

Response time on covert attention task [Once for half an hour]
Time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children
Standard deviation of response time on covert attention task [Once for half an hour]
The variation of the time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children
Correct responses on covert attention task [Once for half an hour]
Number of correct button presses responses (i.e. same side as the target) on the covert attention task on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children
Mean deviation from middle on line bisection task [Once in about 5 minutes]
Mean deviation in mm from the center of the line on the line bisection task for 30 ADHD children and 30 non-ADHD children
Inattention score on the ADHD-RS-IV [Once in about 10 minutes]
The inattention subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children
Hyperactivity/impulsivity score on the ADHD-RS-IV [Once in about 10 minutes]
The hyperactivity/impulsivity subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children

Other Outcome Measures

FSIQ estimation [Once in about 20 minutes]
An estimate of full scale IQ, measured with 2 subtests of the WISC-III for 30 ADHD-children and 30 non-ADHD children

Eligibility Criteria

Criteria

Ages Eligible for Study:

84 Months to 95 Months

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

For both groups

Age between 7 and 10 years of age.
Estimated IQ above 80.
Psychopharmaca- naïve or -free.

For the ADHD-group - A diagnosis of ADHD, classified by the DSM-IV.

Exclusion Criteria:

(Co-morbid) psychiatric disorder (major depression, bipolar disorder, psychotic disorder, chronically motor tic disorder or Gilles de la Tourette, Conduct disorder, autism spectrum disorder, eating disorder, anxiety disorder).
Neurological disorders (e.g. epilepsy) currently or in the past.
Cardiovascular disease currently or in the past.
Serious motor or perceptual handicap.

For the no ADHD-group

No diagnosis of ADHD, classified by the DSM-IV.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging	Nijmegen	Gelderland	Netherlands	6525 EN

Sponsors and Collaborators

Radboud University Medical Center

Investigators

Principal Investigator: Ole Jensen, Prof, Donders Institute for Brain, Cognition and Behavior - Centre for Cognitive Neuroimaging
Principal Investigator: Jan K Buitelaar, Prof, Radboud University, Medical Centre - Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience