International Registry and Biorepository for TMA(Thrombotic Microangiopathy)

Sponsor

Northwell Health (Other)

Overall Status

Terminated

CT.gov ID

NCT00593229

Collaborator

Children's Hospital of Philadelphia (Other), Mario Negri Institute for Pharmacological Research (Other), Icahn School of Medicine at Mount Sinai (Other), University of Virginia (Other), Montreal Children's Hospital of the MUHC (Other), University of Utah (Other), Stollery Children's Hospital (Other), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (NIH)

Enrollment

Location

Study Details

Study Description

Brief Summary

This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy

Condition or Disease	Intervention/Treatment	Phase
Thrombotic Microangiopathy Hemolytic Uremic Syndrome Thrombotic Thrombocytopenic Purpura

Detailed Description

Children age, 6 months - 18 years, are eligible if they have one of the following categories of thrombotic microangiopathy (TMA):(1) severe D+HUS; (2) non-familial atypical HUS; (3) familial atypical HUS; or (4) TTP

Patients are seen intially and annually thereafter

Biosamples are collected for storage annually.

Study Design

Study Type:

Observational

Actual Enrollment :

6 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

An Observational Study of All Forms of Thrombotic Microangiopathy in Pediatric Patients

Study Start Date :

Jan 1, 2007

Actual Primary Completion Date :

Oct 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
3 Familial atypical HUS
4 Thrombotic thrombocytopenic purpura (TTP)
1 Severe diarrhea-associated hemolytic uremic syndrome (D+HUS)
2 Non-familial atypical HUS