Retrieval-extinction Paradigm on Internet Gaming Disorder

• Sponsor: Beijing Normal University (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT04180839
• Collaborator: (none)
• Enrollment: 60
• Location: 1
• Arms: 2
• Anticipated Duration (Months): 5.2
• Patients Per Site Per Month: 11.6

Study Details

Study Description

Brief Summary

The overall aim of this experimental study is to apply the new paradigm of substance addiction intervention to the study of Internet gaming disorder(IGD) subjects' intervention.

Condition or Disease	Intervention/Treatment	Phase
Internet Gaming Disorder	Behavioral: gaming-related retrieval-extinction; Behavioral: nongaming-related retrieval-extinction	N/A

Detailed Description

This study is based on the retrieval-extinction paradigm.As with the efficacy, the experiment aims to test the effect of the retrieval-extinction paradigm on game craving and behave of IGD subjects, so as to provide an empirical basis for the development of effective intervention means of Internet gaming disorder.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 60 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Participant)
• Primary Purpose: Basic Science
• Official Title: Reducing Gaming Cue Reactivity and Behavior Via Retrieval-Extinction Mechanism
• Actual Study Start Date: Nov 25, 2019
• Anticipated Primary Completion Date: Mar 30, 2020
• Anticipated Study Completion Date: Apr 30, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: gaming-related retrieval-extinction about 30 individuals with IGD will be randomly assigned to the R-E training group	Behavioral: gaming-related retrieval-extinction; During one training session,participants will first view a 5-min retrieval video containing gaming content and then, 10 minutes later, receive 1-hour of extinction training in which they will be administered four sequences of video, picture and in vivo gaming cues. The whole training includes 2 training sessions. Participants will receive one training session once a day for two consectutive days.; Other Names: R-E
Other: nongaming-related retrieval-extinction about another 30 individuals with IGD will be randomly assigned to the NR-E training group	Behavioral: nongaming-related retrieval-extinction; During one session,participants will first view a 5-min neutral video and then, 10 minutes later, receive 1-hour of extinction training in which they will be administered four sequences of video, picture and in vivo gaming cues. The whole procedure includes 2 sessions. Participants will receive one session once a day for two consectutive days.; Other Names: NR-E

Outcome Measures

Primary Outcome Measures

1. Mean Change in gaming craving at cue-reactivity task between the two test sessions [baseline , one day after training]

   Participants were asked to passively watch three kinds of videos and rate their craving immediately after each video clip using 10-point visual analog scales.The task assesses the severity of cue-induced craving for Internet gaming, with high scores indicating great cue-induced craving.

Secondary Outcome Measures

1. Mean Change in gaming Craving [The questionnaire is given to participants to record their gaming craving at baseline、after the first day of training、after the second day of training、one day after training、1 week and 1 month after tranning respectively]

   The Brief Questionnaire of gaming Urges questionnaire is a 10-item gaming urge questionnaire with scores ranging from 0 to 10 to assess gaming craving. The questionnaire assesses the severity of craving for Internet gaming behavior, with high scores indicating great craving.

2. Mean Change in gaming time at baseline、1-Week and 1-month Follow-Up [A diary is given to participants to record their gaming time at baseline、 1-week and 1-month]

   At the baseline、end of the first week and month test session, participants will receive a diary in which to record the gaming time after the 1-week and 1-month follow-up period.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 30 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1. the 5th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5 ) recommended diagnosis of Internet gaming disorder : the scores of the 9 items of DSM-5 recommended diagnosis for Internet gaming disorder ≥ 5.

2. the scores of the Young-Internet addiction Test ≥ 50

3. engagement in popular Internet games (e.g. Arena of Valor, League of Legends and Player Unknown's Battle Grounds) for over 20 hours per week for a minimum of 12 months.

Exclusion Criteria:

1. current or history of use of illegal substances and other addictions;

2. current or history of psychiatric or neurological illness;

3. current use of psychotropic medications.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University	Beijing	Beijing	China	100875

Sponsors and Collaborators

• Beijing Normal University

Investigators

• Principal Investigator: jintao Zhang, phD, Beijing Normal University

Study Documents (Full-Text)

None provided.

More Information

Publications

• Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L. A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012 Apr 13;336(6078):241-5. doi: 10.1126/science.1215070.

• Responsible Party: Beijing Normal University
• ClinicalTrials.gov Identifier: NCT04180839
• Other Study ID Numbers: R-E_IGD
• First Posted: Nov 29, 2019
• Last Update Posted: Dec 5, 2019
• Last Verified: Dec 1, 2019

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Internet Addiction Disorder

Study Results

No Results Posted as of Dec 5, 2019