Periodontal Regeneration Using Vitamin A and PRF Compared to PRF Alone Treating Intra-bony Defects
Study Details
Study Description
Brief Summary
Will the addition of vitamin A (Retinol) to PRF add more periodontal regenerative value in the treatment of intra-bony defects compared to PRF alone, clinically?
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Vitamin A has been extensively studied for its role in bone health. Vitamin A can be consumed in two forms, i.e., preformed retinol and pro-vitamin A. Preformed retinol is often found in food originated from animals, such as dairy, liver and eggs. Provitamin A, such as alpha (α)-carotene, beta (β)-carotene orβ-cryptoxanthin, are commonly found in plant-based food, such as fruits and vegetables (Toti et al., 2018). At certain concentrations, it has been proven to enhance the pluripotency of periodontal cells for regeneration (Fawzy El-Sayed, Hein and Dörfer, 2019).
Yet, to the best of our knowledge no clinical trials have evaluated the effect of Vitamin A added to PRF in the regeneration of intra-bony defects. This study is to fill the gap of knowledge.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Group 1 Control PRF in intra-bony defects |
Biological: Platelet Rich Fibrin (PRF)
Platelet rich fibrin (PRF) in treatment of intrabony defects using Modified Minimally invasive surgical technique (M-MIST)
|
| Experimental: Group 2 Experimental PRF and Retinol in intra-bony defects |
Biological: Platelet Rich Fibrin (PRF) and Retinol
Platelet rich fibrin (PRF) mixed with Retinol in treatment of intrabony defects using Modified Minimally invasive surgical technique (M-MIST)
|
Outcome Measures
Primary Outcome Measures
- Radiographic linear defect depth [6 Month]
Measured as the depth of intra-osseous defect from the alveolar crest to the defect base (E et al., 2004)
Secondary Outcome Measures
- Clinical attachment level [6 Month]
clinical attachment level measured in mm. using williams graduated probe(SP, 1967)
- Probing pocket depth [6 Month]
Measuring probing depth in mm using William's graduated Periodontal probe (SP, 1967)
- Radiographic defect bone density [6 MOnth]
Bone density will be measured using Digital Radiographs using ImageJ software (B et al., 2019)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Stage III periodontitis patient (Papapanou et al., 2018) with 3 walled or 2 walled intra-bony defects.
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Non-smokers
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No pregnancy
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Medically free
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Presence of intra-bony defect of three or two walls (as predominant component) with a radiographic intra-bony component of ≥3 mm;
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Presence of ≥2 mm of keratinized gingiva at the tooth with the defect.
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Willingness to optimal compliance with the study procedures
Exclusion Criteria:
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Uncontrolled systemic or local infection in the tissue of interest,
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History or clinical evidence or positive tests for Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV).
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History of chronic autoimmune disease
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Participation in an intervention trial in the same quadrant in the previous two months.
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Type III tooth mobility, vertical root fracture in the selected tooth.
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Contraindications for periodontal surgery.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cairo University | Cairo | Egypt |
Sponsors and Collaborators
- Cairo University
Investigators
- Principal Investigator: Abdallah H. Mostafa, M.Sc, Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 121221