Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects
Study Details
Study Description
Brief Summary
The ideal goal of the periodontal treatment is not only to prevent the progression of the disease, but also the regeneration and reconstruction of lost tissues. Many surgical techniques have been used to regenerate intrabony defects (IBD).
Titanium stimulates activation of the complement system, surface binding of platelets, and platelet activation as reflected by increased levels of platelet-derived growth factor, which is a substantial promoter of bone growth. Hence we may speculate that using a bone substitute made of titanium may be positive from the perspective of bone formation in osseous defects.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Titanium granules consist of irregular porous granules of commercially pure titanium. The porous properties may lead to ingrowth of newly formed bone.The osseointegrating response to titanium may be the result of the potent activation of the intrinsic coagulation system and the subsequent release of growth factors from platelets.Therefore, the aim of this study is to compare the effect of titanium particles and hydroxyapatite on osseous regeneration in intrabony defects.
After reflection of flap and degranulation, bone graft i.e., titanium particles (test group) or hydroxyapatite(control group) will be placed in the void created by the defect and sutures will be placed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Titanium Granules as a bone graft in intrabony defects In test group, after reflection of flap and degranulation, bone graft i.e., titanium particles will be placed in the void created by the defect and sutures will be placed. |
Procedure: Titanium Granules
After degranulation of the intrabony defect, titanium particles will be placed in the defect and will be sutured.
|
| Active Comparator: Hydroxyapatite as a bone graft in intrabony defects In control group, after reflection of flap and degranulation, bone graft i.e., hydroxyapatite will be placed in the defect and sutures will be placed. |
Procedure: Hydroxyapatite
After degranulation of the intrabony defect, hydroxyapatite will be placed in the defect and will be sutured.
|
Outcome Measures
Primary Outcome Measures
- Clinical Attachment Level [from baseline to 6 months]
Assessment of clinical attachment level using UNC-15 probe at baseline and post operatively at 3 and 6 months.
- Probing Depth [from baseline to 6 months]
Assessment of probing depth using University of North Carolina(UNC)-15 probe at baseline and postoperatively at 3 and 6 months.
- Bone Regeneration [at 3 months and 6 months]
Radiovisiography (RVG) will be used to assess bone regeneration achieved post operatively after 3 months and 6 months.
Secondary Outcome Measures
- Plaque Index [from baseline to 6 months]
Assessment of plaque (PI) - according to Turesky modification of Quigley and Hein Plaque Index, 1970.
- Gingivitis [from baseline to 6 months]
Assessment of Gingivitis (GI) - according to Loe H and Silness P, 1963.
Eligibility Criteria
Criteria
Inclusion Criteria:
Systemically healthy male and female patients of age >18 years with two-walled or three-walled intrabony defects and probing pocket depths (PPD) of >3mm.
Exclusion Criteria:
Medically compromised patients, patients <18 years of age, pregnant women, heavy smokers, and patients who underwent radiotherapy or chemotherapy are excluded.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | SVS Institute of Dental Sciences, Mahabubnagar | Hyderabad | Telangana | India | 509002 |
Sponsors and Collaborators
- SVS Institute of Dental Sciences
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SVSIDS/PERIO/4/2020