Evaluation of a Novel Method for Increasing Intraocular Pressure in Healthy Subjects
Study Details
Study Description
Brief Summary
Adequate perfusion is necessary for maintaining tissue function. This applies also for the eye, in which ocular perfusion pressure (OPP) is generally estimated as the difference between mean arterial pressure (MAP) and intraocular pressure (IOP). In the latter formula, IOP substitutes for central retinal venous pressure (CRVP), which is assumed to be slightly higher than IOP to allow blood flow to exit the eye. It has, however, been found that in some patients CRVP is elevated and significantly higher than IOP, which would lead to a decrease in OPP which is not taken in account with the proposed formula. Therefore, techniques for measurement of CRVP are warranted. Recently, a new, method for measurement of this parameter without corneal contact has been introduced. Briefly, with this method, IOP is elevated until the vein collapses, which then equals CRVP. In the present study this technique will be applied in 12 healthy subjects to validate whether the values that are preset by the device correlate to measurements obtained with standard Goldmann applanation tonometry. For this purpose, IOP will be experimentally increased in steps of approximately 5mmHg until it reaches 40mmHg as measured by applanation tonometry. After a resting period of 30 minutes, IOP will be again increased stepwise to 40 mmHg while retinal vessel diameters will be monitored using dynamic vessel analyzer. During this session CRVP will be measured. After another resting period of 30 minutes IOP will be stepwise increased a third time and after each step OCT, OCT-A and OCT EDI will be performed.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: IOPstim
|
Device: IOPstim
IOPstim (IMEDOS, Jena, Germany) is a device exerting defined pressure to the sclera and hence increasing IOP.
Device: Suction Cup
Suction Cup is a device exerting defined suction to the clear and hence increasing IOP
|
Outcome Measures
Primary Outcome Measures
- Intraocular pressure (IOP) [15 Minutes]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Men and women aged between 18 and 35 years
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Non-smokers
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Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
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Normal ophthalmic findings, ametropia < 1 Dpt.
Exclusion Criteria:
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Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
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Treatment in the previous 3 weeks with any drug (except contraceptives)
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Symptoms of a clinically relevant illness in the 3 weeks before the first study day
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Blood donation during the previous 3 weeks
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Pregnancy, planned pregnancy or lactating
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Clinical Pharmacology, Medical University of Vienna | Vienna | Austria |
Sponsors and Collaborators
- Medical University of Vienna
Investigators
- Principal Investigator: Gerhard Garhöfer, MD, Department of Clinical Pharmacology, Medical University of Vienna
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- OPHT-120219