MG: Study on Intraocular Structural Parameters and Surgical Effect Before and After the Onset of Malignant Glaucoma

Sponsor

Zhongshan Ophthalmic Center, Sun Yat-sen University (Other)

Overall Status

Unknown status

CT.gov ID

NCT04220879

Collaborator

(none)

Enrollment

Location

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In this retrospective observational study, we collected intraocular structure parameters of malignant glaucoma and primary angle closure glaucoma. Anterior chamber depth (ACD) and width (ACW), lens vault (LV), ciliary process-ciliary process distance(CCD), trabecular-ciliary processes distance (TCPD), ciliary body max thickness (CBMT), peripheral iris thickness (PIT), trabecular ciliary process angle (TCPA), and anterior vault (AV), were measured by ultrasound biomicroscopy. Other parameters measured by A-scan ultrasonography and optical coherence tomography. To analyze the high risk factors and the possible pathogenesis of the disease and discuss the long-term effect of different treatment methods.

Condition or Disease	Intervention/Treatment	Phase
Glaucoma Malignant Glaucoma

Detailed Description

Outcome Measures:

Anterior chamber depth (ACD) and width (ACW), lens vault (LV), ciliary process-ciliary process distance(CCD), trabecular-ciliary processes distance (TCPD), ciliary body max thickness (CBMT), peripheral iris thickness (PIT), trabecular ciliary process angle (TCPA), and anterior vault (AV), were measured by ultrasound biomicroscopy. Other parameters measured by A-scan ultrasonography and optical coherence tomography.

Study Design

Study Type:

Observational

Anticipated Enrollment :

60 participants

Observational Model:

Case-Control

Time Perspective:

Other

Official Title:

Study on Intraocular Structural Parameters and Surgical Effect Before and After the Onset of Malignant Glaucoma

Actual Study Start Date :

Nov 25, 2019

Anticipated Primary Completion Date :

Aug 24, 2020

Anticipated Study Completion Date :

Nov 24, 2020

Arms and Interventions

Arm	Intervention/Treatment
Malignant Glaucoma To determine the biometric measurements.
Fellow Eyes To determine the biometric measurements.
Matched Eyes To determine the biometric measurements.

Outcome Measures

Primary Outcome Measures

Trabecular ciliary process angle [baseline]
TCPA is measured with its apex at the scleral spur, one arm along the posterior corneal surface, and another arm along the most anterior surface of the ciliary body
Choroidal vascularity parameter [baseline]
Choroidal vascularity parameter is a vessel ratio measured by optical coherence tomographic images

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria: (1) history of operation, (2) diagnosis of MG, and (3) eyes with clear optical media.

Exclusion Criteria:(1)hypertension or diabetes and (2) diagnosis of ocular fundus diseases.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Zhognshan Ophthalmic Center, Sun Yat-sen University	Guangzhou	Guangdong	China	510060

Sponsors and Collaborators

Zhongshan Ophthalmic Center, Sun Yat-sen University

Investigators

Study Director: Chengguo O Zuo, Zhognshan Ophthalmic Center, Sun Yat-sen University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Zhongshan Ophthalmic Center, Sun Yat-sen University

ClinicalTrials.gov Identifier:

NCT04220879

Other Study ID Numbers:

2019KYPJ148

First Posted:

Jan 7, 2020

Last Update Posted:

Jan 7, 2020

Last Verified:

Jan 1, 2020

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Zhongshan Ophthalmic Center, Sun Yat-sen University

Malignant Glaucoma

Biometric Measurements

Additional relevant MeSH terms:

Glaucoma

Study Results

No Results Posted as of Jan 7, 2020