Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain

• Sponsor: Milton S. Hershey Medical Center (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT05650008
• Collaborator: (none)
• Enrollment: 30
• Anticipated Duration (Months): 5.9

Study Details

Study Description

Brief Summary

The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).

Condition or Disease	Intervention/Treatment	Phase
Left Ventricular Dysfunction; Spinal Anesthetics Causing Adverse Effects in Therapeutic Use; Global Cardiac Wall Motion Dysfunction	Drug: Intrathecal local anesthesia

Study Design

• Study Type: Observational
• Anticipated Enrollment: 30 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
• Anticipated Study Start Date: Jan 1, 2023
• Anticipated Primary Completion Date: Jun 1, 2023
• Anticipated Study Completion Date: Jul 1, 2023

Outcome Measures

Primary Outcome Measures

1. Left Ventricular Global Longitudinal Strain [5 minutes]

Secondary Outcome Measures

1. Left Ventricular Ejection Fraction [5 minutes]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Adult patients undergoing elective knee and hip replacements under spinal anesthesia

Exclusion Criteria:

• Patients who do not wish to consent

• Patients with contraindications to TTE

• Patients with reduced left ventricular systolic function as defined by LV ejection fraction < 50% on pre-operative echocardiography

• Patients with body mass index greater than 40

• Non-English-speaking subjects

• Cognitively impaired adults

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Milton S. Hershey Medical Center

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Christopher Cowart, Assistant Professor of Anesthesiology & Perioperative Medicine, Milton S. Hershey Medical Center
• ClinicalTrials.gov Identifier: NCT05650008
• Other Study ID Numbers: 21263
• First Posted: Dec 14, 2022
• Last Update Posted: Dec 14, 2022
• Last Verified: Dec 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Undecided
• Plan to Share IPD: Undecided
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Christopher Cowart, Assistant Professor of Anesthesiology & Perioperative Medicine, Milton S. Hershey Medical Center: Strain
• Additional relevant MeSH terms: Ventricular Dysfunction; Ventricular Dysfunction, Left; Anesthetics

Study Results

No Results Posted as of Dec 14, 2022