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Comparison of Hemodynamic Changes With Morphine Versus Esmolol During Induction of Anaesthesia

Sponsor
Pakistan Navy Station Shifa Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT06065956
Collaborator
(none)
110
Enrollment
1
Location
2
Arms
10.5
Actual Duration (Months)
10.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Comparing hemodynamic changes with morphine versus esmolol as an adjuvant agent during induction of Anaesthesia

Condition or Disease Intervention/Treatment Phase
  • Drug: Intravenous morphine
 Phase 1/Phase 2

Detailed Description

Comparing hemodynamic profile of patients during induction of General Anesthesia with intravenous morphine as an adjuvant drug versus Intravenous esmolol as an adjuvant agent,My aim is to study which drug has superior hemodynamic profile in terms of hemodynamic stability of patient requiring General Anesthesia.

Study Design

Study Type:
Interventional
Actual Enrollment :
110 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Supportive Care
Official Title:
Comparison of Hemodynamic Changes With Morphine Versus Esmolol as an Adjuvant Agent During Induction of Anaesthesia
Actual Study Start Date :
Aug 28, 2022
Actual Primary Completion Date :
Jun 15, 2023
Actual Study Completion Date :
Jul 15, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Morphine group

Half of participants will be comprising of morphine group

Drug: Intravenous morphine
Morphine group(an opioid), participants were given intravenous morphine(an opioid) at induction of General Anaesthesia before laryngoscopy and intubation. The other group,Esmolol group(cardioselective beta blocker), participants were given intravenous esmolol(cardioselective beta blocker) during induction of General Anesthesia before laryngoscopy and intubation.
Other Names:
  • Intravenous esmolol

    		•
    Experimental: Esmolol group

    Half of participants will be comprising of esmolol group

    Drug: Intravenous morphine
    Morphine group(an opioid), participants were given intravenous morphine(an opioid) at induction of General Anaesthesia before laryngoscopy and intubation. The other group,Esmolol group(cardioselective beta blocker), participants were given intravenous esmolol(cardioselective beta blocker) during induction of General Anesthesia before laryngoscopy and intubation.
    Other Names:
  • Intravenous esmolol

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Blood pressure [06 months]

      Change in blood pressure between baseline value and post Intubation value will be measured in millimeter of mercury (mmHg).

    2. Pulse rate [06 months]

      Change in pulse rate between baseline value and post intubation value will be measured per minute.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    25 Years to 55 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • ASA 2 patients presenting for elective surgery.
    Exclusion Criteria:

    • Patients having major cardiac disease.

    • Metastatic disease.

    • Pregnant females.

    • Those unwilling to be part of study.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 PNS Shifa Hospital Karachi Sind Pakistan 46000

    Sponsors and Collaborators

    • Pakistan Navy Station Shifa Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Kenan Anwar Khan, FCPS 2 Registrar in Anaesthesiology, Pakistan Navy Station Shifa Hospital
    ClinicalTrials.gov Identifier:
    NCT06065956
    Other Study ID Numbers:
    • 433/8/22
    First Posted:
    Oct 4, 2023
    Last Update Posted:
    Oct 4, 2023
    Last Verified:
    Oct 1, 2023
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Morphine
    Esmolol

    Study Results

    No Results Posted as of Oct 4, 2023