To Investigate the Impact of Analgesic Management Guided by qNOX Monitoring on the Comfort and Prognosis of Mechanically Ventilated ICU Patients
Study Details
Study Description
Brief Summary
Purpose: To explore the effect of analgesic management under the guidance of qNOX monitoring on the comfort level and prognosis of patients with mechanical ventilation in ICU.
Method:After admission to ICU, the patients were randomly divided into the analgesia group guided by BPS（Behavioral Pain Scale） and physiological indicators monitoring and qNOX-guided analgesia group (qNOX group). Sedation and analgesia program after admission to ICU (continuous injection pump) : propofol 1.5-4.5mg/kg.h, remifentanil 5-8ug/kg.h, maintain sedation goals RASS（Richmond Agitation-Sedation Scale）-3 to -4 scores, BPS（Behavioral Pain Scale）3 to 4 scores. The researchers worked with the bedside nurse to plan different care procedures, including :1) central venous catheter or arterial catheter puncture; 2) The patient is turned over completely so that the back can be washed and the sheets changed; 3) Endotracheal sputum aspiration (patients with intubation or in tracheotomy state ); 4) Dressing the wound.
Primary outcome:Value of qNOX at BPS（Behavioral Pain Scale）≥5 (qNOX sensitivity, specificity, positive predictive value and negative predictive value) Secondary outcome:To investigate the patient baseline variables that may affect qNOX; Variables that may influence qNOX in relation to critical illness.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| BPS（Behavioral Pain Scale）and physiological index monitoring guided analgesia group
|
|
| Analgesia group guided by qNOX
|
Device: qNOX
Non
|
Outcome Measures
Primary Outcome Measures
- Value of qNOX with BPS≥5 [During procedure]
Sensitivity, specificity, positive predictive value and negative predictive value of qNOX.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients aged 18 years or older who are undergoing abdominal, orthopedic, ENT（ear-nose-throat）, urological, neurosurgical or cardiothoracic surgery and require ICU treatment with mechanical ventilation while having an RASS（Richmond Agitation-Sedation Scale）-3 or -4 score;
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Patients unable to self-assess pain intensity using NRS（Numerical Pain Rating Scale）;
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Patients who have provided informed consent.
Exclusion Criteria:
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< 18 years of age;
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Pregnant individuals;
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Patients with communication impairments, such as those who have experienced cerebrovascular accidents;
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A decision to withdraw life-sustaining treatment or an unstable medical condition that disrupts planned routine care.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Tianjin Medical University General Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GWang009