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Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects

Sponsor
The University of Hong Kong (Other)
Overall Status
Unknown status
CT.gov ID
NCT03058354
Collaborator
(none)
6,000
Enrollment
1
Location
48
Anticipated Duration (Months)
125.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Propofol is a commonly used anaesthetic with rapid recovery and less side effects and total intravenous anaesthesia (TIVA) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery.

Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result.

The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016.

Condition or Disease Intervention/Treatment Phase

Detailed Description

Objectives:

  1. To investigate the analgesic effects of propofol.

  2. To evaluate the effect of propofol on postoperative adverse events.

Methods:

Retrospective audit.

Data Collection:

  1. Demographic data;

  2. Types of analgesic techniques;

  3. Type of pain relief modalities;

  4. Pain score up to 72 hours postoperatively;

  5. Postoperative opioid consumption;

  6. Incidence of adverse events during APS care;

  7. Patients' satisfaction on pain relief.

Study Design

Study Type:
Observational
Anticipated Enrollment :
6000 participants
Observational Model:
Other
Time Perspective:
Retrospective
Official Title:
Retrospective Study to Investigate Total Intravenous Anaesthesia (TIVA) With Propofol on Postoperative Pain and Side Effects After Surgery
Actual Study Start Date :
Jan 1, 2017
Anticipated Primary Completion Date :
Dec 31, 2019
Anticipated Study Completion Date :
Dec 31, 2020

Arms and Interventions

Arm Intervention/Treatment
Group TIVA

Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using intraoperative TIVA with propofol.

Drug: Propofol
Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using intraoperative TIVA with propofol.
Group GA

Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using general anaesthesia methods other than intraoperative TIVA with propofol.

Procedure: general anaesthesia
Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using general anaesthesia methods other than intraoperative TIVA with propofol.

Outcome Measures

Primary Outcome Measures

  1. pain score [up to postoperative day 3]

    pain score using numeral rating scale

Secondary Outcome Measures

  1. analgesic consumption [up to postoperative day 3]

    analgesic consumption base on patient drug record

Eligibility Criteria

Criteria

Ages Eligible for Study:
N/A and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Anaesthetic records and acute pain service records of patient undergone surgery between 2014 to 2016 in Queen Mary Hospital would be retrieved from the computer.
Exclusion Criteria:

  • Essential data were missing.

  • Patient participating in other research projects.

  • Changes in postoperative pain management technique.

  • Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Contacts and Locations

Locations

Site City State Country Postal Code
1 The University of Hong Kong Hong Kong Hong Kong

Sponsors and Collaborators

  • The University of Hong Kong

Investigators

  • Principal Investigator: Stanley SC Wong, MBBS, The University of Hong Kong

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Wong Sau Ching Stanley, Clinical Assistant Professor, The University of Hong Kong
ClinicalTrials.gov Identifier:
NCT03058354
Other Study ID Numbers:
  • UW17-001
First Posted:
Feb 20, 2017
Last Update Posted:
Jan 25, 2019
Last Verified:
Jan 1, 2019
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Pain, Postoperative
Propofol

Study Results

No Results Posted as of Jan 25, 2019