InvestiCAT: Investigating Cardiovascular Adverse Events Related to Cancer Treatment

Sponsor

University Medical Center Groningen (Other)

Overall Status

Recruiting

CT.gov ID

NCT03199300

Collaborator

(none)

Enrollment

Location

72.6

Anticipated Duration (Months)

0.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Cisplatin, anthracyclines, bleomycin and trastuzumab can cause severe cardiovascular or pulmonary toxicity. Why some patients are susceptible to extreme toxicity of cancer treatment is largely unknown. Unraveling extreme cardiovascular toxic responses in cancer patients may help understand the pathophysiology of cardiovascular toxicity of these agents and help in understanding the more subtle, long-term cardiovascular side effects that affect a larger part of cancer survivors. With induced pluripotent stem cells we will obtain patient-derived cells to recapitulate and mimic and study pathological (cardiovascular) responses and (cardiovascular) toxicity in vitro.

Condition or Disease	Intervention/Treatment	Phase
Toxicity Due to Chemotherapy Cardiovascular Morbidity Cancer, Treatment-Related	Drug: Anthracyclines Drug: Trastuzumab Drug: Cisplatin Drug: Bleomycin

Study Design

Study Type:

Observational

Anticipated Enrollment :

48 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Investigating Cardiovascular Adverse Events Related to Cancer Treatment: a Study of Extreme Toxicity Using Induced Pluripotent Stem Cells

Actual Study Start Date :

Dec 12, 2017

Anticipated Primary Completion Date :

Jan 1, 2024

Anticipated Study Completion Date :

Jan 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Anthracylines-treated with toxicity Patients with toxicity during/after treatment with anthracylines.	Drug: Anthracyclines Chemotherapy regimen containing anthracyclines.
Anthracyclines-treated without toxicity Patients without toxicity during/after treatment with anthracylines.	Drug: Anthracyclines Chemotherapy regimen containing anthracyclines.
Trastuzumab-treated with toxicity Patients with toxicity during/after treatment with trastuzumab.	Drug: Trastuzumab Systemic treatment including trastuzumab.
Trastuzumab-treated without toxicity Patients without toxicity during/after treatment with trastuzumab.	Drug: Trastuzumab Systemic treatment including trastuzumab.
Cisplatin-treated with toxicity Patients with toxicity during/after treatment with cisplatin.	Drug: Cisplatin Chemotherapy including cisplatin.
Cisplatin-treated without toxicity Patients without toxicity during/after treatment with cisplatin.	Drug: Cisplatin Chemotherapy including cisplatin.
Bleomycin-treated with toxicity Patients with toxicity during/after treatment with bleomycin.	Drug: Bleomycin Chemotherapy including bleomycin.
Bleomycin-treated without toxicity Patients without toxicity during/after treatment with bleomycin.	Drug: Bleomycin Chemotherapy including bleomycin.

Outcome Measures

Primary Outcome Measures

Comparison between iPSC-derived cells [3 years]
Comparison between iPSC-derived cells from toxicity cases and controls, for each of the four different agents.

Secondary Outcome Measures

Correlate the findings from the iPSC-derived cells with the clinical phenotype of cardiovascular toxicity [3 years]
Correlate the findings from the iPSC-derived cells with the clinical phenotype of (cardiovascular) toxicity, assessed by circulating biomarkers and cardiac or vascular imaging.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

In order to be eligible to participate in this study, a subject must meet all of these criteria:

any proven cancer treated with curative intent;
age ≥ 18 and ≤ 50 years;
able to comply with the protocol;
signed written informed consent.

There are specific inclusion criteria for every subject group:

severe toxicity during 1 to 3 cycles of anthracyclines;
≥ 3 months after end of cancer treatment which included the maximum tolerable dose of anthracyclines without (severe) toxicity;
severe toxicity within 1 to 6 cycles of trastuzumab;
≥ 3 months after end of cancer treatment which included a year of trastuzumab without (severe) toxicity.
severe toxicity during 1 to 3 cycles of cisplatin;
≥ 1 year after end of cancer treatment which included high-dose cisplatin without toxicity;
severe toxicity during 1 to 3 cycles of bleomycin;
≥ 1 year after end of cancer treatment which included high-dose bleomycin without toxicity.

Severe toxicity is defined as any of grade 3 - 4 toxicity according to CTCAE 4.03.

A potential subject who meets any of the following exclusion criteria will be excluded from participation in this study:

history of cardiovascular disease prior to start of cancer treatment, as evidenced by any of the following: symptomatic or treated cardiovascular disease prior to start of cancer treatment; LVEF < 55% at any performed MUGA scan or echocardiography prior to start of cancer treatment;
any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol, or insufficient understanding of the Dutch language;
any contraindication for skin biopsy, including: extensive skin disorder precluding biopsy of unaffected skin; known allergy to local anaesthetics; use of anticoagulants and INR > 3;
pregnant or lactating female.

Furthermore, there are specific exclusion criteria for the control groups:

history of cardiovascular disease during or after cancer treatment, as evidenced by any of the following: any symptomatic or treated cardiovascular disease; LVEF < 55% at any performed MUGA scan or echocardiography.