Study Investigating MEN1 and SDHD in Familial Carcinoid Tumors

Sponsor

Rutgers University (Other)

Overall Status

Unknown status

CT.gov ID

NCT00672269

Collaborator

(none)

Enrollment

Location

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

There is a high incidence among the first degree relatives of the carcinoid patients, indicating the involvement of genetic components in its initiation and pathogenesis.

Condition or Disease	Intervention/Treatment	Phase
Carcinoid Neuroendocrine Cancer

Detailed Description

This proposed pilot study will conduct detailed interviews into the medical, environmental, and family histories and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.

Study Design

Study Type:

Observational

Anticipated Enrollment :

25 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

A Pilot Study to Investigate Germ-Line MEN1 and SDHD Gene Mutation in Familial Cases of Carcinoid Cancer

Study Start Date :

Apr 1, 2008

Anticipated Primary Completion Date :

Apr 1, 2009

Anticipated Study Completion Date :

Jun 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
1 Families with carcinoid in multiple family members

Outcome Measures

Primary Outcome Measures

Mutations in MEN1 and SDHD genes [1 year]

Eligibility Criteria

Criteria

Ages Eligible for Study:

12 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Over the age of 18 years
More than one ,member of a family with a history of biopsy confirmed carcinoid tumor
English speaking
Mentally and emotionally capable of answering questions
Willing and available for study participation
At least one other family member with carcinoid tumor

Exclusion Criteria:

If you are under the age of 18 years,
If you are unable to understand or unable to provide informed consent,
If you have a psychological condition (i.e. depression, anxiety disorder, substance abuse, etc.) which might cause you significant problems in dealing with test results.