Active-AMI: Investigating the Role of Active Versus Chronic Coronary Artery Calcification on Acute Myocardial Infarct

Sponsor

National Heart Centre Singapore (Other)

Overall Status

Completed

CT.gov ID

NCT03712020

Collaborator

Singapore General Hospital (Other)

Enrollment

52.9

Actual Duration (Months)

Study Details

Study Description

Brief Summary

The investigator aims to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart.

The patient cohort will consist of patients diagnosed to have either acute coronary syndrome (ACS) (comprising of either unstable angina pectoris or acute myocardial infarction) or suspected coronary artery disease (CAD). The PET images will be compared to images obtained from standard contrast CT of the coronaries. This study will provide additional insights about active versus non-active calcification amongst patients with ACS or suspected CAD.

Condition or Disease	Intervention/Treatment	Phase
Chest Pain

Detailed Description

Contemporary techniques used to visualize coronary artery calcification include standard non-contrast computed tomography (CT) of the coronaries measuring amount of calcium deposition in the coronaries, contrast CT and more recently, using sodium-fluoride (Na-F) positron emission tomography (PET) to image coronary and valvular calcification. Na-F has been shown to accumulate in areas of active calcification where contrast CT of the heart has been shown to accumulate in areas of chronic calcification. The investigator aims to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart.

Study Design

Study Type:

Observational

Actual Enrollment :

15 participants

Observational Model:

Other

Time Perspective:

Prospective

Official Title:

Investigating the Role of Active Versus Chronic Coronary Artery Calcification on Acute Myocardial Infarct: A Novel Pilot Study Using Sodium-Fluoride Positron Emission Tomography (PET) and Computed Tomography (CT) Techniques

Actual Study Start Date :

Feb 1, 2015

Actual Primary Completion Date :

Mar 1, 2016

Actual Study Completion Date :

Jul 1, 2019

Outcome Measures

Primary Outcome Measures

Coronary artery calcification will be determined by Tc-99m MDP SPECT-CT and Na-F PET-CT [12 months]
Na-F has been shown to accumulate in areas of active calcification where contrast CT of the heart has been shown to accumulate in areas of chronic calcification. We aim to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart.

Eligibility Criteria

Criteria

Ages Eligible for Study:

50 Years to 89 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients with a diagnosis of acute coronary syndrome
Patients referred for workup of suspected coronary syndrome
Able to provide written, informed consent.
Age between (including) 50 years to 89 years old.

Exclusion Criteria:

Pregnant & Lactating women
weight <=180kg

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

National Heart Centre Singapore
Singapore General Hospital

Investigators

Principal Investigator: Angela Koh, National Heart Centre

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

National Heart Centre Singapore

ClinicalTrials.gov Identifier:

NCT03712020

Other Study ID Numbers:

2014/2183

First Posted:

Oct 19, 2018

Last Update Posted:

Jun 24, 2020

Last Verified:

Jun 1, 2020

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Additional relevant MeSH terms:

Myocardial Infarction

Chest Pain

Study Results

No Results Posted as of Jun 24, 2020