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Investigation of Plasma Proteins in Patients With Hereditary Haemorrhagic Telangiectasia and PAVMs

Sponsor
Imperial College London (Other)
Overall Status
Unknown status
CT.gov ID
NCT00230672
Collaborator
(none)
70
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels, including arteriovenous malformations in the lungs (PAVMs). We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of several proteins in the blood stream. We propose to take blood samples from patients at defined times in order to study changes in blood protein levels and activity

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    70 participants
    Time Perspective:
    Prospective
    Official Title:
    Studies of Plasma Proteins Derived From Pulmonary Arteriovenous Malformation Patients
    Study Start Date :
    Mar 1, 2005

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No

      Inclusion Criteria:Patients with hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations -

      Exclusion Criteria:Unable to provide informed consent

      -

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Imperial College Hammersmith Campus London United Kingdom W12 0NN

      Sponsors and Collaborators

      • Imperial College London

      Investigators

      • Principal Investigator: Claire Shovlin, Imperial College London

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00230672
      Other Study ID Numbers:
      • IC/CLS7
      First Posted:
      Oct 3, 2005
      Last Update Posted:
      Aug 13, 2008
      Last Verified:
      Aug 1, 2008
      Additional relevant MeSH terms:
      Telangiectasis
      Telangiectasia, Hereditary Hemorrhagic

      Study Results

      No Results Posted as of Aug 13, 2008