An Investigation of Small Intestinal Carcinoid Carcinoma in Families

Sponsor

Rutgers University (Other)

Overall Status

Unknown status

CT.gov ID

NCT00662168

Collaborator

(none)

Enrollment

Location

Duration (Months)

0.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This proposed pilot study is to conduct detailed interviews into the medical, environmental, and family histories The second phase of this study project is to and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) and stored for a second phase of this pilot. The purpose is to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.

Condition or Disease	Intervention/Treatment	Phase
Carcinoid Carcinoma

Detailed Description

There have not been any studies published which specifically describe the medical, environmental, and genetic factors in carcinoid tumors cases that have carcinoid in family members. While rare, with an incidence of four per 100, 000, carcinoid represents the most frequent malignancy affecting the small intestine. Because nearly half (49%) of the cases of gastrointestinal carcinoid tumors have hepatic metastasis at diagnosis, identification of the risk factors associated with carcinoid has the potential to increase early diagnosis and cure. Carcinoid tumors are thought to occur spontaneously and not associated with an inherited genetic abnormality that would increase a family member's risk for developing carcinoid cancer. There is a known inherited genetic abnormality that is associated with bronchial carcinoid tumors but only less than 10%. Gastrointestinal carcinoid tumors are not thought to be associated with a inherited genetic abnormality. There have been several small studies that have examined gastrointestinal carcinoid in multiple family members. It remains uncertain if these cases of carcinoid in multiple family members are characteristic of a heritable or environmental etiology. Most carcinoid cancer is not inherited; however, less than 10% of neuroendocrine carcinoid cancer is thought to be due to a change (called a "mutation") in a gene inherited from a parent. There are several genes that are suspected to be associated with carcinoid cancer, two of interest in this study is the Multiple Endocrine Neoplasia Type1 (MEN1), and succinate dehydrogenase complex, subunit D (SDHD) genes.

Study Design

Study Type:

Observational

Anticipated Enrollment :

8 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

An Investigation of Eight Reported Cases of Small Intestinal Carcinoid Carcinoma in Multiple Family Members

Study Start Date :

Jan 1, 2008

Anticipated Primary Completion Date :

Nov 1, 2008

Anticipated Study Completion Date :

Nov 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
observation Individuals with a diagnosis of carcinoid carcinoma

Outcome Measures

Primary Outcome Measures

identification of carcinoid in multiple family members [lifetime history]

Eligibility Criteria

Criteria

Ages Eligible for Study:

12 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Over the age of 18 years
History of biopsy confirmed small intestinal carcinoid tumor
English speaking
Mentally and emotionally capable of answering questions
Willing and available for study participation
At least one first-degree family member with carcinoid tumor

Exclusion Criteria:

If you are under the age of 18 years,
If you have any mental or memory impairments
If you are unable to understand the information in the informed consent document.