Ion Channel Genetic Biomarkers: Diagnostic Capabilities in the Assessment of Bipolar Disorder
Study Details
Study Description
Brief Summary
Genotype 164 adults to evaluate six selected single nucleotide polymorphisms (SNPs) (rs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582) for use as a genetic biomarker to differentiate between bipolar depression and unipolar depression.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Adults ages 18-80 will be recruited if they are diagnosed with bipolar disorder, major depression, or have no mood symptoms. The adults will undergo a diagnostic interview, the Mini International Neuropsychiatric Interview (MINI) for the diagnosis. The subjects will also complete the Adverse Childhood Events Scale to evaluate for a genetic x environmental interaction in detecting bipolar disorder at initial assessment. Genotyping will be done by SNaPshot genotyping method and genetic sample will be collected via buccal swab.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Bipolar Diagnosed as having at least 1 lifetime manic episode by the MINI |
Other: genotyping all subjects
genotyping using SNaPshot genotyping method.
|
| Depression Diagnosed as having at least 1 Major Depressive Episode by the MINI |
Other: genotyping all subjects
genotyping using SNaPshot genotyping method.
|
| Healthy Controls Does not meet Criteria for any mood disorder diagnosis (MDD, BD, dysthymia) |
Other: genotyping all subjects
genotyping using SNaPshot genotyping method.
|
Outcome Measures
Primary Outcome Measures
- Logistic Regression [1 year]
Logistic regression will be used to examine a genetic risk score using a risk allele count as the independent variable, with a diagnosis of BD versus MDD versus those with no mood diagnosis as the dependent variable.
Secondary Outcome Measures
- Genetic Risk Score [1 year]
Genetic risk score of selected SNPsrs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582
- Family History [1 year]
Positive family history of bipolar disorder in a first degree relative
- Adverse Childhood Experiences Scale [1 year]
0-10 item scale assessing for adversity experienced during childhood
Eligibility Criteria
Criteria
Inclusion Criteria:
-
presenting to one of 4 Denver Metro Area clinics
-
Subjects must fall into one of 3 diagnostic categories, bipolar, MDD, or no mood symptoms.
Exclusion Criteria:
-
Inability to provide informed consent
-
history of TBI
-
history of untreated seizure disorder
-
substance abuse in the last 8 hours
-
moderate-severe substance abuse disorder diagnosed in the last 6 months
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Helen and Arthur E Johnson Depression Center | Aurora | Colorado | United States | 80045 |
Sponsors and Collaborators
- University of Colorado, Denver
- Sigma Theta Tau
Investigators
- Principal Investigator: Kristiana Avery, PhD-c, University of Colorado, Denver
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 17-1578