Iron Status in Women of Reproductive Age Reproductive Age
Study Details
Study Description
Brief Summary
Analyzed iron status, HFE mutations and ethnicity for women in five primary care centers in the United States and Canada using de-identified data from the HEIRS study.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
HEIRS included a cross-sectional screening study of 101,168 patients, 25 years of age or older, in the primary care setting. Participants were recruited from four centers in the U.S .and one in Canada from February 2001 to February 2003. We will evaluate results for women aged 25-44 years of age who are self-reported as Asian, Black, Hispanic or White. The lower detection limit for the serum ferritin (SF) assay in the HEIRS study was 15 μg/L and therefore the definition of iron deficiency will be SF concentration ≤ 15 μg/L. Elevated SF concentrations, possibly indicative of elevated iron stores, will be classified by two definitions: 1) SF concentration > 300 μg/L and 2) SF >200 μg/L in combination with TSAT
45%. Proportions will be compared by Pearson's chi-square. Logistic regression models will be used to identify independent associations with measures of iron deficiency and elevated iron stores.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Asian American non-pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as Asian American and non-pregnant/non-breastfeeding. |
Other: observation
observation
|
| African American non-pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as African American and non-pregnant/non-breastfeeding. |
Other: observation
observation
|
| Hispanic American non-pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as Hispanic American and non-pregnant/non-breastfeeding. |
Other: observation
observation
|
| White non-pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as white and non-pregnant/non-breastfeeding. |
Other: observation
observation
|
| Asian American pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as Asian American and pregnant or breastfeeding. |
Other: observation
observation
|
| African American pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as African American and pregnant or breastfeeding. |
Other: observation
observation
|
| Hispanic American pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as Hispanic American and pregnant or breastfeeding. |
Other: observation
observation
|
| White pregnant Women 25 to 44 years of age recruited in a primary care setting and self reported as White and pregnant or breastfeeding. |
Other: observation
observation
|
Outcome Measures
Primary Outcome Measures
- Elevated serum ferritin [One measurement was made at the time of recruitment and this is the measurement that will be analyzed.]
Serum ferritin >300 ug/L
- Elevated serum ferritin and transferrin saturation [One measurement was made at the time of recruitment and this is the measurement that will be analyzed.]
Serum ferritin >200 ug/L and transferrin saturation >45%
- Iron deficiency [One measurement was made at the time of recruitment and this is the measurement that will be analyzed.]
Serum ferritin <15ug/L
Eligibility Criteria
Criteria
Inclusion Criteria:
-
primary care women included in the HEIRS study with in the age range of this study
-
Self designation as Asian American, African American, Hispanic American or White.
Exclusion Criteria:
-
Age >44 years
-
Self-described ethnicity other in than inclusion criterion 2.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Illinois at Chicago | Chicago | Illinois | United States | 60612 |
Sponsors and Collaborators
- Victor Gordeuk
- Weill Medical College of Cornell University
Investigators
- Principal Investigator: Victor R Gordeuk, MD, University of Illinois at Chicago
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HEIRS-womenrepage