IBSET: Ethosuximide to Treat IBS

Sponsor

University Hospital, Clermont-Ferrand (Other)

Overall Status

Recruiting

CT.gov ID

NCT02973542

Collaborator

SFETD (Socièté Française d'Etude et de Traitement de la Douleur) (Other)

286

Enrollment

Location

Arms

Anticipated Duration (Months)

4.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Abdominal pain remains the most deleterious symptom for patients with irritable bowel syndrome (IBS) and is causing a significant alteration of their quality of life. The visceral hypersensitivity seems to be one of the key mechanisms that could explain the abdominal pain in these patients. Current treatments, mainly symptomatic, are of limited effectiveness, especially in terms of relief of abdominal pain. The study will aim to evaluate the effectiveness of ethosuximide on abdominal pain in patients with IBS, its tolerance and its impact on patient quality of life, severity of symptoms related to IBS and the use of analgesics / antispasmodic / regulators transit.

Condition or Disease	Intervention/Treatment	Phase
Irritable Bowel Syndrome	Drug: Ethosuximide Other: Placebo	Phase 2

Detailed Description

The irritable bowel syndrome (IBS) is characterized by a combination of discomfort and / or abdominal pain and bowel habits in the absence of identifiable organic pathology. This condition is extremely common because it is the first cause of consultation in gastroenterology and would cover 10-15% of the French. This chronic condition, although functional, impact significantly on the quality of life of patients and causes considerable health spending, making it a major public health problem. Especially as the currently used treatments are of limited effectiveness.

Among the pathophysiological mechanisms involved in IBS, visceral hypersensitivity (VHS) seems to be a major factor causing pain in patients. VHS involves sensitization of colonic nerve fibers, resulting in an increase of neuronal excitability. In several animal models of chronic pain, this hyperexcitability was related to a change in the expression or activity of ion channels, including calcium channel Cav3.2.

Investigators especially shown the involvement of Cav3.2 channels in visceral pain in an animal model of VHS. Furthermore, overexpression of these channels at the peripheral level (dorsal root ganglion innervating the colon) has been demonstrated in this animal model and pharmacological blockade, including ethosuximide, prevented the development of the VHS. Note that Cav3.2 channels have been widely demonstrated as involved in nociceptive phenomena in various animal models of chronic pain and that by blocking their ethosuximide induce an analgesic effect in these models.

Finally, we have recently demonstrated the involvement of Cav3.2 channel in patients with IBS, in a clinical case-control study. The Cav3.2 channels were overexpressed in the colonic mucosa of patients with IBS compared to asymptomatic controls.

The Cav3.2 channels are therefore a potential pharmacological target and ethosuximide a promising therapy to effectively treat the abdominal pain associated with IBS.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

286 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Treatment

Official Title:

Evaluation of the Efficacy and Tolerance of Ethosuximide in the Treatment of Abdominal Pain Associated With Irritable Bowel Syndrome

Actual Study Start Date :

Apr 30, 2018

Anticipated Primary Completion Date :

Feb 1, 2023

Anticipated Study Completion Date :

Jul 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: ethosuximide A responder will correspond to a decrease in abdominal pain score (11-points NRS pain) of at least 30% compared to the score before treatment and a score of 6 or 7 on the SGA scale. At endpoint (12-weeks treatment period), it will be compared the responder rate between the 2 treatment arms (ethosuximide vs placebo).	Drug: Ethosuximide The study will aim to evaluate the effectiveness of ethosuximide on abdominal pain in patients with IBS, its tolerance and its impact on patient quality of life, severity of symptoms related to IBS and the use of analgesics / antispasmodic / regulators transit.
Placebo Comparator: placebo A responder will correspond to a decrease in abdominal pain score (11-points NRS pain) of at least 30% compared to the score before treatment and a score of 6 or 7 on the SGA scale. At endpoint (12-weeks treatment period), it will be compared the responder rate between the 2 treatment arms (ethosuximide vs placebo).	Other: Placebo The study will aim to evaluate the effectiveness of ethosuximide on abdominal pain in patients with IBS, its tolerance and its impact on patient quality of life, severity of symptoms related to IBS and the use of analgesics / antispasmodic / regulators transit.

Arm

Intervention/Treatment

Experimental: ethosuximide

A responder will correspond to a decrease in abdominal pain score (11-points NRS pain) of at least 30% compared to the score before treatment and a score of 6 or 7 on the SGA scale. At endpoint (12-weeks treatment period), it will be compared the responder rate between the 2 treatment arms (ethosuximide vs placebo).

Drug: Ethosuximide

The study will aim to evaluate the effectiveness of ethosuximide on abdominal pain in patients with IBS, its tolerance and its impact on patient quality of life, severity of symptoms related to IBS and the use of analgesics / antispasmodic / regulators transit.

Placebo Comparator: placebo

Other: Placebo

Outcome Measures

Primary Outcome Measures

30% reduction in abdominal pain [through study completion, an average of 12 weeks.]
Score of 4 or 5 on the SGA scale [through study completion, an average of 12 weeks.]

Secondary Outcome Measures

Monthly assessment of abdominal pain [at 1 month]
Monthly assessment of score of Bristol scale [at 1 month]
Monthly evaluation of GIQLI questionnaire [at 1 month]
Monthly evaluation of EQ-5D questionnaire [at 1 month]
Monthly evaluation of IBS-SSS questionnaire [at 1 month]
Monthly evaluation of SGA scale. [at 1 month]
Monthly evaluation of the use of analgesics [at 1 month]
Monthly evaluation of the use of antispasmodic [at 1 month]
Monthly evaluation of the use of regulators transit. [at 1 month]
Monthly evaluation of medical response rate [at 1 month]
Monthly evaluation of stop work related to IBS. [at 1 month]
Evaluation of the tolerance of ethosuximide throughout the study. [at 1 month]
Evaluation of the discontinuation rate study because of adverse events throughout the study [at 1 month]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Age ≥ 18 years,
Man,
Women, Negative pregnancy test and effective contraception,
IBS defined by the Rome criteria IV
During the previous seven days the inclusion visit, average NRS pain ≥ 4,
IBS Treatment stable for 1 month
Patients affiliated to the French Social Security,
Patients with the informed consent were obtained.

Exclusion Criteria:

Breastfeeding
Diabetic patients
Known renal or hepatic impairment,
Significant liver function abnormalities (transaminases> 3N, cholestasis) and renal (MDRD <60 ml / min)
Addiction to alcohol and / or drugs,
AEDs taken (epilepsy or chronic pain)
chronic pain of greater intensity than that related to IBS,
Allergy succinimides (ethosuximide, methsuximide, phensuximide)
History or current severe depression (hospitalization, long-term antidepressant treatment)
Psychotic disorders,
Patients exclusion period, or total exceeded authorized allowances
Patients undergoing a measure of legal protection (trusteeship, guardianship ...).