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The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Sponsor
Konkuk University Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT02756715
Collaborator
(none)
80
Enrollment
1
Location
2
Arms
44.9
Actual Duration (Months)
1.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Condition or Disease Intervention/Treatment Phase
  • Drug: propofol group
  • Drug: Desflurane group
 N/A

Detailed Description

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

  1. Preoperation (immediate before anesthesia induction)

  2. Immediate before tourniquet off

  3. 5 min after tourniquet off

  4. PACU

  5. postoperative 6 hours

  6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Study Design

Study Type:
Interventional
Actual Enrollment :
80 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Investigator)
Primary Purpose:
Basic Science
Official Title:
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
Actual Study Start Date :
May 30, 2016
Actual Primary Completion Date :
Mar 26, 2018
Actual Study Completion Date :
Feb 27, 2020

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: propofol group

The patient who anesthetized by using propofol.

Drug: propofol group
Patient will be anesthetized by using propofol infusion during operation.
Other Names:
  • Propofol

    		•
    Active Comparator: Desflurane group

    The patient who anesthetized by using sevoflurane.

    Drug: Desflurane group
    Patient will be anesthetized by using desflurane inhalation during operation.
    Other Names:
  • Desflurane

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Syndecan-1 [Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours]

      change of level of syndecan-1 (scores range from 0 to 100)

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • patients who was planned to undergo knee surgery.
    Exclusion Criteria:

    • age < 20 years old

    • history of previous cancer

    • history of previous peripheral vascular disease

    • Emergency surgery

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Konkuk University Medical Center Seoul Korea, Republic of 143-729

    Sponsors and Collaborators

    • Konkuk University Medical Center

    Investigators

    • Principal Investigator: Seong-Hyop Kim, M.D,Ph.D, Konkuk University Medical Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Seong-Hyop Kim, Associate Professor, Konkuk University Medical Center
    ClinicalTrials.gov Identifier:
    NCT02756715
    Other Study ID Numbers:
    • KUH1160100
    First Posted:
    Apr 29, 2016
    Last Update Posted:
    Feb 28, 2020
    Last Verified:
    Feb 1, 2020
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Additional relevant MeSH terms:
    Vascular System Injuries
    Ischemia
    Propofol
    Desflurane

    Study Results

    No Results Posted as of Feb 28, 2020